| Granulocyte-Colony stimulating factor and macrophage-colony stimulating factor in patients with non-small-cell lung cancer. | |
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MedLine Citation:
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PMID: 11434384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have investigated the serum level of granulocyte-colony stimulating factor (G-CSF) and macrophagecolony stimulating factor (M-CSF) in non-small-cell lung cancer (NSCLC), in relation to the control group and commonly accepted tumor markers, such as carcinoembryonic antigen (CEA) and cytokeratin fragment 19 (CYFRA 21-1). Additionally, we have defined the diagnostic sensitivity, specificity, positive predictive value, negative predictive value and receiver-operating characteristics (ROC) curve of G-CSF and M-CSF. Serum levels of cytokines were measured in 61 patients with NSCLC and in 20 healthy subjects. G-CSF and M-CSF were determined using ELISA. CYFRA 21-1 was measured by radioimmunoassay and CEA by microparticle enzyme immunoassay. There were significant increases in the level of circulating G-CSF in the lung cancer patients compared to the control group. Moreover, the diagnostic sensitivity of G-CSF was higher (56%) than the sensitivity of CYFRA 21-1 (51%), but lower than the CEA sensitivity (62%). The diagnostic specificity of G-CSF was higher (70%) than the M-CSF specificity (40%) and the G-CSF predictive values were higher in relation to the predictive values of M-CSF. These results suggest a potential role of G-CSF as a tumor marker for NSCLC. |
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Authors:
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B Mroczko; M Szmitkowski; J Niklinski |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical chemistry and laboratory medicine : CCLM / FESCC Volume: 39 ISSN: 1434-6621 ISO Abbreviation: Clin. Chem. Lab. Med. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-07-03 Completed Date: 2001-12-04 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9806306 Medline TA: Clin Chem Lab Med Country: Germany |
Other Details:
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Languages: eng Pagination: 374-9 Citation Subset: IM |
Affiliation:
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Department of Biochemical Diagnostics, Medical Academy, Bialystok, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens, Neoplasm / blood Carcinoembryonic Antigen / blood Carcinoma, Non-Small-Cell Lung / blood*, diagnosis Enzyme-Linked Immunosorbent Assay False Negative Reactions Female Granulocyte Colony-Stimulating Factor / blood* Humans Keratin-19 Keratins Lung Neoplasms / blood*, diagnosis Macrophage Colony-Stimulating Factor / blood* Male Middle Aged Predictive Value of Tests ROC Curve Radioimmunoassay Sensitivity and Specificity Tumor Markers, Biological / blood* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Carcinoembryonic Antigen; 0/Keratin-19; 0/Tumor Markers, Biological; 0/antigen CYFRA21.1; 143011-72-7/Granulocyte Colony-Stimulating Factor; 68238-35-7/Keratins; 81627-83-0/Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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