Document Detail

Granulocyte-Colony stimulating factor and macrophage-colony stimulating factor in patients with non-small-cell lung cancer.
MedLine Citation:
PMID:  11434384     Owner:  NLM     Status:  MEDLINE    
We have investigated the serum level of granulocyte-colony stimulating factor (G-CSF) and macrophagecolony stimulating factor (M-CSF) in non-small-cell lung cancer (NSCLC), in relation to the control group and commonly accepted tumor markers, such as carcinoembryonic antigen (CEA) and cytokeratin fragment 19 (CYFRA 21-1). Additionally, we have defined the diagnostic sensitivity, specificity, positive predictive value, negative predictive value and receiver-operating characteristics (ROC) curve of G-CSF and M-CSF. Serum levels of cytokines were measured in 61 patients with NSCLC and in 20 healthy subjects. G-CSF and M-CSF were determined using ELISA. CYFRA 21-1 was measured by radioimmunoassay and CEA by microparticle enzyme immunoassay. There were significant increases in the level of circulating G-CSF in the lung cancer patients compared to the control group. Moreover, the diagnostic sensitivity of G-CSF was higher (56%) than the sensitivity of CYFRA 21-1 (51%), but lower than the CEA sensitivity (62%). The diagnostic specificity of G-CSF was higher (70%) than the M-CSF specificity (40%) and the G-CSF predictive values were higher in relation to the predictive values of M-CSF. These results suggest a potential role of G-CSF as a tumor marker for NSCLC.
B Mroczko; M Szmitkowski; J Niklinski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical chemistry and laboratory medicine : CCLM / FESCC     Volume:  39     ISSN:  1434-6621     ISO Abbreviation:  Clin. Chem. Lab. Med.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-07-03     Completed Date:  2001-12-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9806306     Medline TA:  Clin Chem Lab Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  374-9     Citation Subset:  IM    
Department of Biochemical Diagnostics, Medical Academy, Bialystok, Poland.
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MeSH Terms
Antigens, Neoplasm / blood
Carcinoembryonic Antigen / blood
Carcinoma, Non-Small-Cell Lung / blood*,  diagnosis
Enzyme-Linked Immunosorbent Assay
False Negative Reactions
Granulocyte Colony-Stimulating Factor / blood*
Lung Neoplasms / blood*,  diagnosis
Macrophage Colony-Stimulating Factor / blood*
Middle Aged
Predictive Value of Tests
ROC Curve
Sensitivity and Specificity
Tumor Markers, Biological / blood*
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Carcinoembryonic Antigen; 0/Keratin-19; 0/Tumor Markers, Biological; 0/antigen CYFRA21.1; 143011-72-7/Granulocyte Colony-Stimulating Factor; 68238-35-7/Keratins; 81627-83-0/Macrophage Colony-Stimulating Factor

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