Document Detail


Granulocytapheresis for the Treatment of Severe Alcoholic Hepatitis: A Case Series and Literature Review.
MedLine Citation:
PMID:  24052196     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Severe alcoholic hepatitis has a high mortality rate due to limited therapeutic methods. Although corticosteroids have been used to control the inflammatory response, the outcomes vary and no standardized therapy has been established. Novel therapeutic approaches, such as anti-TNF-α, pentoxifilline, and others have been tested clinically on the basis of their cytokinemic pathophysiology with limited success. However, treatment of leukocytosis that causes cytokinemia and hepatic inflammation in patients via granulocytapheresis and leukocytapheresis showed promising results in a number of reports. Here, we report two cases of severe alcoholic hepatitis treated with granulocytapheresis. The liver function and inflammation recovered after the therapy. A review of 35 cases treated with granulocytapheresis and leukocytapheresis demonstrated their efficacy in treating alcoholic hepatitis by controlling leukocytosis as well as cytokines such as IL-8. Multidisciplinary treatment for severe alcoholic hepatitis should be considered case by case on the basis of the complexity and severity of the condition.
Authors:
Kenya Kamimura; Michitaka Imai; Akira Sakamaki; Shigeki Mori; Masaaki Kobayashi; Ken-Ichi Mizuno; Manabu Takeuchi; Takeshi Suda; Minoru Nomoto; Yutaka Aoyagi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-20
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  -     ISSN:  1573-2568     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachido-ri, Chuo-ku, Niigata, 951-8510, Japan, kenya-k@med.niigata-u.ac.jp.
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