| Granulocyte-macrophage colony-stimulating factor enhances wound healing in diabetes via upregulation of proinflammatory cytokines. | |
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MedLine Citation:
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PMID: 19799605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chronic ulceration, especially in diabetes, remains a substantial clinical problem. Exogenous granulocyte-macrophage colony-stimulating factor (GM-CSF) is efficacious in the treatment of chronic wound healing in both animal models and patients, but its role in diabetic wounds remains to be explored. Objectives Using a diabetic mouse model, to investigate the role of GM-CSF in wound healing. METHODS: Clinical observation, histopathology, immunohistochemistry and cytokine assays. RESULTS: There was a significant reduction (50%) in GM-CSF production in the wounds of the diabetics compared with nondiabetics. Exogenous GM-CSF substantially enhanced the wound healing in diabetic mice, accompanied by increased interleukin-6 and monocyte chemoattractant protein-1 production. The elevated cytokines correlated with increased neovascularization, and infiltration of macrophages and neutrophils. GM-CSF showed no beneficial effects in nondiabetic wound healing. CONCLUSIONS: Our results provide useful guidelines for the clinical management of chronic ulceration in diabetes. |
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Authors:
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Y Fang; J Shen; M Yao; K W Beagley; B D Hambly; S Bao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-03 |
Journal Detail:
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Title: The British journal of dermatology Volume: 162 ISSN: 1365-2133 ISO Abbreviation: Br. J. Dermatol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0004041 Medline TA: Br J Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 478-86 Citation Subset: IM |
Affiliation:
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Department of Plastic Surgery, School of Medicine, Shanghai Third People's Hospital, Shanghai Jiaotong University, Shanghai, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Chemokine CCL2 / biosynthesis Collagen / metabolism Colony-Stimulating Factors / metabolism* Cytokines / metabolism* Diabetes Mellitus, Experimental / metabolism* Female Granulocyte-Macrophage Colony-Stimulating Factor / metabolism* Interleukin-6 / biosynthesis Male Mice Mice, Knockout Models, Animal Neovascularization, Physiologic / physiology Up-Regulation / physiology* Wound Healing / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Ccl2 protein, mouse; 0/Chemokine CCL2; 0/Colony-Stimulating Factors; 0/Cytokines; 0/Interleukin-6; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor; 9007-34-5/Collagen |
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