Document Detail

Granulation tissue proliferation during isotretinoin treatment.
MedLine Citation:
PMID:  2939033     Owner:  NLM     Status:  MEDLINE    
Excessive, pseudotumoral granulation tissue proliferations appeared in three patients receiving isotretinoin for nodulocystic acne. A review of the literature disclosed few reports of this unusual adverse reaction. Two clinical patterns have been reported; one in a periungual location and the other occurring in the sites of acne lesions during isotretinoin therapy. Loose edematous connective tissue with small vessels and chronic inflammatory infiltrate were the histologic findings in all three cases.
L Puig; A Moreno; E Llistosella; X Noguera; J M de Moragas
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  25     ISSN:  0011-9059     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-06-02     Completed Date:  1986-06-02     Revised Date:  2006-10-30    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  191-3     Citation Subset:  IM    
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MeSH Terms
Acne Vulgaris / drug therapy
Connective Tissue / pathology
Granulation Tissue / drug effects*,  pathology
Skin / pathology
Tretinoin / adverse effects*,  therapeutic use
Reg. No./Substance:
302-79-4/Tretinoin; 4759-48-2/Isotretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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