| Granulated lysozyme as an alternative to antibiotics improves growth performance and small intestinal morphology of 10-day-old pigs. | |
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MedLine Citation:
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PMID: 22064735 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Lysozyme is a 1,4-β-N-acetylmuramidase that has antimicrobial properties. The objective of this experiment was to determine the effect of a purified granulated lysozyme, compared to antibiotics, on growth performance, small intestinal morphology, and Campylobacter shedding in 10-d-old pigs. Forty-eight pigs (n = 16), with an initial weight of 4.0 ± 0.1 kg (P > 0.40) were weaned at 10 d of age, blocked by litter and gender, and assigned to pens (8 pigs/pen). Each block was randomly assigned to consume 1 of 3 liquid dietary treatments for 14 d; control, control + lysozyme (100 mg/kg diet), or control + antibiotics (neomycin and oxytetracycline, 16 mg/kg diet). Pigs were weighed and bled on d 0, 7, and 14. Blood was analyzed for plasma urea nitrogen (PUN) and IgA. After 14 d of treatment, pigs were killed and samples of jejunum and ileum were collected and fixed to measure villus height and crypt depth. Rectal swabs were taken on d 0, 7, and 14 of treatment, and samples of ileal and cecal contents were taken at d 14 of treatment to determine the presence of Campylobacter. Pigs consuming lysozyme and antibiotics gained at a faster rate than control pigs over the course of the study (402 ± 12 and 422 ± 14 kg/d, respectively vs. 364 ± 14 g/d; P < 0.02), resulting in heavier ending BW (9.9 ± 0.3, 9.9 ± 0.3, and 9.0 ± 0.2 kg for lysozyme, antibiotic, and control pigs, respectively; P < 0.03). Immunoglobulin A decreased and PUN increased over the course of the study (P < 0.1), regardless of dietary treatment (P > 0.6). Crypt depth was increased in lysozyme and antibiotic-fed pigs, compared to control pigs, in both jejunum (60.0 ± 2.8 and 62.2 ± 3.0, respectively vs. 50.7 ± 3.1 µm; P < 0.03) and ileum (76.0 ± 7.5 and 72.2 ± 5.0, respectively vs. 52.4 ± 3.5 µm; P < 0.02). Villus height did not differ in the jejunum (P > 0.2), but was increased in the ileum of pigs consuming lysozyme and antibiotic diets, compared to control pigs (312 ± 20 and 314 ± 10, respectively vs. 263 ± 15 µm; P < 0.4). Small intestinal total mucosa and mucosal protein concentration, as well as disaccharidase-specific activities, were not altered by lysozyme or antibiotics (P > 0.05). Campylobacter was detected in 27% of control samples, but in only 5% of antibiotic-fed samples and 8% of lysozyme-fed samples (P < 0.01). Thus, granulated lysozyme is a suitable alternative to antibiotics for 10-d-old pigs consuming manufactured liquid diets. |
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Authors:
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K D May; J E Wells; C V Maxwell; W T Oliver |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
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Title: Journal of animal science Volume: - ISSN: 1525-3163 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003002 Medline TA: J Anim Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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University of Arkansas, Fayetteville, AR 72701. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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