Document Detail

Granular parakeratosis: a case report and literature review.
MedLine Citation:
PMID:  12753175     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Granular parakeratosis is suspected to result from an error in epidermal differentiation, leading to variably pruritic, hyperpigmented-to-erythematous patches and plaques. Characteristic histopathologic features include a thickened stratum corneum, compact parakeratosis with retention of keratohyalin granules, vascular proliferation, and ectasia. The pathogenesis of this entity is uncertain. METHODS: We present a case of axillary granular parakeratosis and review the literature. RESULTS: The lesion showed a thickened stratum corneum with compact parakeratosis, slight epidermal hyperplasia, and a sparse perivascular lymphohistiocytic infiltrate. Keratohyalin granules were diffusely present within the parakeratotic stratum corneum, and the retained granular layer showed focal vacuolization. CONCLUSIONS: Granular parakeratosis is a rare form of parakeratosis most often seen in the axilla, although other intertriginous areas may be affected. Unique histopathologic findings allow for a specific diagnosis to be made. Although an irritant contact reaction appears causative, mechanical irritation may also play a role in inducing these skin changes.
Christopher A Wallace; Rita O Pichardo; Gil Yosipovitch; John Hancox; Omar P Sangueza
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  30     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-19     Completed Date:  2003-12-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  332-5     Citation Subset:  IM    
Department of Dermatology, Wake Forest University Baptist Medical Center, Winston-Salem, NC, USA.
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MeSH Terms
Administration, Topical
Axilla* / pathology
Parakeratosis / drug therapy,  etiology,  pathology*
Triamcinolone / administration & dosage,  therapeutic use
Reg. No./Substance:

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