| Granular natural-killer cells develop into mucus-secreting cells. | |
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MedLine Citation:
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PMID: 3876279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Colonies of granular natural-killer cells selectively develop in lymph-node cell cultures of nude mice after stimulation with rat T-cell growth factor. When these cells are grown on X-irradiated monolayers prepared from 16-18-day-old mouse embryos, they are triggered to synthesize and secrete a sulphated glycoprotein that can be identified as mucus. As a result of an erosive process of the granules, the mucoid material accumulates in pools in the cytoplasm matrix. The secretion is operated through a process of budding of double-membrane-bound vesicles. The successful triggering of mucous synthesis is interpreted by the successful growth of those mesenchymal cells in the embryonic monolayer that function in the induction of epithelial morphogenesis in the developing embryo. |
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Authors:
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H Ginsburg; T Yehuda-Cohen; R Coleman; Z Lapidot; Y Hecht; A Kinarty |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Immunology letters Volume: 10 ISSN: 0165-2478 ISO Abbreviation: Immunol. Lett. Publication Date: 1985 |
Date Detail:
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Created Date: 1985-10-31 Completed Date: 1985-10-31 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7910006 Medline TA: Immunol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 271-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Clone Cells / cytology, secretion Cytotoxicity, Immunologic Embryo, Mammalian Interleukin-2 / immunology Killer Cells, Natural / cytology, immunology, secretion* Mice Mice, Inbred Strains Mice, Nude Microscopy, Electron Mucus / secretion* |
| Grant Support | |
ID/Acronym/Agency:
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AI 16255/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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