Document Detail


Granular natural-killer cells develop into mucus-secreting cells.
MedLine Citation:
PMID:  3876279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Colonies of granular natural-killer cells selectively develop in lymph-node cell cultures of nude mice after stimulation with rat T-cell growth factor. When these cells are grown on X-irradiated monolayers prepared from 16-18-day-old mouse embryos, they are triggered to synthesize and secrete a sulphated glycoprotein that can be identified as mucus. As a result of an erosive process of the granules, the mucoid material accumulates in pools in the cytoplasm matrix. The secretion is operated through a process of budding of double-membrane-bound vesicles. The successful triggering of mucous synthesis is interpreted by the successful growth of those mesenchymal cells in the embryonic monolayer that function in the induction of epithelial morphogenesis in the developing embryo.
Authors:
H Ginsburg; T Yehuda-Cohen; R Coleman; Z Lapidot; Y Hecht; A Kinarty
Related Documents :
17471539 - Sinistral equal-size spiral cleavage of the indirectly developing polychaete hydroides ...
10393819 - Energy metabolism during embryonic development and larval growth of an antarctic sea ur...
16665929 - Comparison of starch and adp-glucose pyrophosphorylase levels in nonembryogenic cells a...
16001259 - Gypsy embryo specifies ovule curvature by regulating ovule/integument development in rice.
5002429 - Determination of blastoderm cells in drosophila melanogaster.
3203909 - The developmental fate of androgenetic, parthenogenetic, and gynogenetic cells in chime...
22569789 - Regulation of mouse intestinal l cell progenitors proliferation by the glucagon family ...
23555309 - Twist1 controls a cell-specification switch governing cell fate decisions within the ca...
1865199 - Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and d...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunology letters     Volume:  10     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-31     Completed Date:  1985-10-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  271-80     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Clone Cells / cytology,  secretion
Cytotoxicity, Immunologic
Embryo, Mammalian
Interleukin-2 / immunology
Killer Cells, Natural / cytology,  immunology,  secretion*
Mice
Mice, Inbred Strains
Mice, Nude
Microscopy, Electron
Mucus / secretion*
Grant Support
ID/Acronym/Agency:
AI 16255/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Interleukin-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of ascorbic acid on human natural killer cells.
Next Document:  Establishment and biological activity of a proliferative anti-idiotype-activated T cell line.