Document Detail

Granular natural-killer cells develop into mucus-secreting cells.
MedLine Citation:
PMID:  3876279     Owner:  NLM     Status:  MEDLINE    
Colonies of granular natural-killer cells selectively develop in lymph-node cell cultures of nude mice after stimulation with rat T-cell growth factor. When these cells are grown on X-irradiated monolayers prepared from 16-18-day-old mouse embryos, they are triggered to synthesize and secrete a sulphated glycoprotein that can be identified as mucus. As a result of an erosive process of the granules, the mucoid material accumulates in pools in the cytoplasm matrix. The secretion is operated through a process of budding of double-membrane-bound vesicles. The successful triggering of mucous synthesis is interpreted by the successful growth of those mesenchymal cells in the embryonic monolayer that function in the induction of epithelial morphogenesis in the developing embryo.
H Ginsburg; T Yehuda-Cohen; R Coleman; Z Lapidot; Y Hecht; A Kinarty
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Immunology letters     Volume:  10     ISSN:  0165-2478     ISO Abbreviation:  Immunol. Lett.     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-31     Completed Date:  1985-10-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7910006     Medline TA:  Immunol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  271-80     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation
Clone Cells / cytology,  secretion
Cytotoxicity, Immunologic
Embryo, Mammalian
Interleukin-2 / immunology
Killer Cells, Natural / cytology,  immunology,  secretion*
Mice, Inbred Strains
Mice, Nude
Microscopy, Electron
Mucus / secretion*
Grant Support
Reg. No./Substance:

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