Document Detail


Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction.
MedLine Citation:
PMID:  20299008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Nicotine is the principal component of tobacco smoke, resulting in addiction, and recent evidence suggests that damage to the insular cortex (insula) disrupts tobacco addiction in human smokers. However, the effect of an inactivation of this structure in an animal model of nicotine addiction has yet to be evaluated.
METHODS: To study this question, we investigated the effects of reversible inactivation of the granular insula by local injection of a gamma-aminobutyric acid agonists mixture (baclofen/muscimol) on nicotine self-administration (SA) under fixed and progressive ratio and on reinstatement of nicotine seeking induced by nicotine priming or nicotine-associated cues in rats. We also evaluated the effects of granular insula inactivation on food SA and relapse as a control.
RESULTS: The inactivation of the granular insula decreased nicotine SA under both fixed and progressive ratios without affecting the SA of food under the same schedules of reinforcement. This inactivation also prevented the reinstatement, after extinction, of nicotine seeking induced by nicotine-associated cues or nicotine priming without modifying the reinstatement of food seeking.
CONCLUSIONS: Our study indicates that the integrity of the granular insula is necessary for exhibiting motivation to take nicotine and to relapse to nicotine seeking but not for consuming food pellets or to relapse for food seeking. Indeed, it might be interesting to study the effect of methods that are able to modulate the activity of the insula--such as repetitive transcranial magnetic stimulation or deep brain stimulation--on tobacco addiction and relapse in humans.
Authors:
Benoit Forget; Abhiram Pushparaj; Bernard Le Foll
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-17
Journal Detail:
Title:  Biological psychiatry     Volume:  68     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-71     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
Affiliation:
Translational Addiction Research Laboratory, Pharmacology and Psychiatry, Institutes of Medical Sciences, University of Toronto, Toronto, Canada.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Association Learning / drug effects
Baclofen / administration & dosage
Behavior, Addictive / prevention & control*
Behavior, Animal / drug effects
Cerebral Cortex / cytology,  drug effects*,  physiology
Conditioning, Classical / drug effects
Disease Models, Animal
Drug Combinations
Extinction, Psychological / drug effects
GABA Agonists / administration & dosage*
Male
Microinjections
Motivation / physiology
Muscimol / administration & dosage
Nicotine / pharmacology*
Nicotinic Agonists / pharmacology*
Rats
Reinforcement Schedule
Self Administration
Tobacco Use Disorder / prevention & control*
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/GABA Agonists; 0/Nicotinic Agonists; 1134-47-0/Baclofen; 2763-96-4/Muscimol; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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