Document Detail


Granisetron attenuates exercise-induced conditioned taste aversion in the rat.
MedLine Citation:
PMID:  15927732     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A conditioned taste aversion (CTA) paradigm was used in the present study to investigate whether CTA produced by exercise could be attenuated by the 5-HT(3) receptor antagonist granisetron. Male Sprague-Dawley rats were randomly allocated to one of four groups (Ns=6) and were exposed to salty (0.128 M sodium chloride) or sour (0.00138M citric acid) solutions. Subjects were injected with either saline solution (1.0 ml, 0.9%) or granisetron (0.5mg/kg, IP) and were exposed to 30 min of forced wheel running exercise (70 revolutions/30min) 10 min after injection. Exercise induced CTA to both the salty (3.7 ml intake) and sour-flaroured (3.1ml intake) solutions as compared with no exercise (intake 14.0 and 13.7 ml), and administration of granisetron significantly attenuated the exercise-induced CTA to the salty- and sour-flavoured solutions.
Authors:
S Eccles; E-M Kim; E O'Hare
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-12
Journal Detail:
Title:  Appetite     Volume:  44     ISSN:  0195-6663     ISO Abbreviation:  Appetite     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-01     Completed Date:  2005-09-26     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  8006808     Medline TA:  Appetite     Country:  England    
Other Details:
Languages:  eng     Pagination:  325-8     Citation Subset:  IM    
Affiliation:
School of Psychology, University of Ulster (Jordanstown), Shore Road, Newtownabbey, Co. Antrim BT37 OQB, Northern Ireland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Avoidance Learning / drug effects*
Granisetron / pharmacology*
Male
Physical Conditioning, Animal
Random Allocation
Rats
Rats, Sprague-Dawley
Serotonin Antagonists / pharmacology*
Taste / drug effects*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Serotonin Antagonists; 109889-09-0/Granisetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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