Document Detail

Graft protection in organ transplantation.
MedLine Citation:
PMID:  18494399     Owner:  NLM     Status:  MEDLINE    
Preserving donor organs in optimal condition is a prerequisite for successful transplantation. The donor organ is subjected to a multitude of stresses. In this review, we will discuss the consequences of brain death on donor organs. The effects of an extended ischaemic period followed by the reperfusion necessary for the harvest, storage and implantation of transplant organs will be evaluated. As progressively more is known about the underlying pathophysiological mechanisms, focused and efficient therapeutic interventions can be developed. We will review current organ protection techniques and look at possible future strategies to further improve the final donor organ quality.
Paul Herijgers; Willem J Flameng
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical anaesthesiology     Volume:  22     ISSN:  1521-6896     ISO Abbreviation:  Best Pract Res Clin Anaesthesiol     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-05-22     Completed Date:  2008-08-07     Revised Date:  2011-04-28    
Medline Journal Info:
Nlm Unique ID:  101121446     Medline TA:  Best Pract Res Clin Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  225-39     Citation Subset:  IM    
Department of Cardiovascular Diseases, Division of Experimental Cardiac Surgery, Provisorium I, Minderbroedersstraat 15, 3000 Leuven, Belgium.
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MeSH Terms
Brain Death / physiopathology*
Organ Preservation / methods*
Organ Transplantation / methods*,  statistics & numerical data
Time Factors
Transplantation Conditioning / methods*

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