| Graft protection in organ transplantation. | |
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MedLine Citation:
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PMID: 18494399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preserving donor organs in optimal condition is a prerequisite for successful transplantation. The donor organ is subjected to a multitude of stresses. In this review, we will discuss the consequences of brain death on donor organs. The effects of an extended ischaemic period followed by the reperfusion necessary for the harvest, storage and implantation of transplant organs will be evaluated. As progressively more is known about the underlying pathophysiological mechanisms, focused and efficient therapeutic interventions can be developed. We will review current organ protection techniques and look at possible future strategies to further improve the final donor organ quality. |
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Authors:
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Paul Herijgers; Willem J Flameng |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Best practice & research. Clinical anaesthesiology Volume: 22 ISSN: 1521-6896 ISO Abbreviation: Best Pract Res Clin Anaesthesiol Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-05-22 Completed Date: 2008-08-07 Revised Date: 2011-04-28 |
Medline Journal Info:
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Nlm Unique ID: 101121446 Medline TA: Best Pract Res Clin Anaesthesiol Country: England |
Other Details:
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Languages: eng Pagination: 225-39 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Diseases, Division of Experimental Cardiac Surgery, Provisorium I, Minderbroedersstraat 15, 3000 Leuven, Belgium. paul.herijgers@med.kuleuven.be |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Death / physiopathology* Humans Organ Preservation / methods* Organ Transplantation / methods*, statistics & numerical data Time Factors Transplantation Conditioning / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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