Document Detail

Gradual Versus Sudden Weaning From Nasal CPAP in Preterm Infants: A Pilot Randomized Control Trial.
MedLine Citation:
PMID:  22906960     Owner:  NLM     Status:  Publisher    
BACKGROUND: There is paucity of information on the weaning of nasal continuous positive airway pressure (NCPAP) in preterm infants. As the weaning from NCPAP can be gradual or sudden we wanted to determine which of the two methods was better. METHODS: A prospective randomized trial was conducted to compare the success of weaning from NCPAP when using the sudden and gradual weaning methods in infants born <or=32 weeks. We also compared the weight, post-menstrual age (PMA) when these infants were successfully weaned off from NCPAP and their length of stay (LOS) in the hospital. RESULTS: Of the 56 infants included in the study, 28 infants were randomized to each weaning method. The gestational age, birth weight and other clinical factors were similar between the two groups. There was no difference in the rate of success of initial weaning between the 2 methods (p=0.65). The infants were successfully weaned off at 33.7±2.8 weeks versus 33.8±2.6 weeks (p=0.93) PMA and at 1736±487 grams versus 1736±501 grams (p=0.99) weight in sudden wean and gradual wean groups respectively. The LOS was 61.3±19.6 days for the sudden wean group and 66.0±27.1 days for the gradual wean group (p=0.48). CONCLUSION: There was no difference in the success of weaning off NCPAP between the 2 weaning methods. The weight and PMA at the time of successful NCPAP wean also did not differ between the two groups. These findings suggest that factors other than the method of CPAP wean, such as pulmonary maturity, may determine the success of NCPAP wean in preterm infants.
Shantanu Rastogi; Wendy Wong; Anju Gupta; Alok Bhutada; Deepa Rastogi
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-16
Journal Detail:
Title:  Respiratory care     Volume:  -     ISSN:  0020-1324     ISO Abbreviation:  Respir Care     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7510357     Medline TA:  Respir Care     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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