Document Detail

Grades 1 and 2 hypothyroidism in a state mental hospital: risk factors and clinical findings.
MedLine Citation:
PMID:  3104944     Owner:  NLM     Status:  MEDLINE    
Thirty-six chronically psychotic patients (nine men and 27 women, mean age 56.7 +/- S.D. 13.4 years) were found to have elevated thyroid stimulating hormone (TSH) levels during review of thyroid function screening tests of 1150 patients over a 15 month period in a 700 bed state mental hospital. This study population of 36 patients was more likely to be female and older than the general hospital population. The spectrum and frequency of psychiatric diagnoses included dementia (3); schizoaffective disorder (12); bipolar disorder (6); schizophrenic disorder (4); organic affective disorder (7); major depression (3); and mental retardation (1). Only nine of these 36 patients failed to receive the goitrogens lithium (LI), carbamazepine (CBZ) and/or phenytoin (PTN) and five of those nine patients had a history of thyroid disease. Sex did not predict age, thyroxine (T4) level, triiodothyronine (T3) uptake, or TSH. The distribution of psychiatric diagnoses were the same for both sexes. Expectedly, there was an inverse relationship between TSH and T4 and T3 uptake. Using T4 to separate grades 1 and 2 hypothyroidism revealed that six (17%) patients had grade 1 disease. Men were more likely to have a seizure disorder and receive LI, CBZ, and PTN. Women were more likely to have a history of thyroid disease. The goitrogenic effects of LI + CBZ seemed additive compared with patients receiving LI alone. While T4, T3 uptake, and LI levels were the same for the two groups, patients receiving LI + CBZ had higher TSH values (p = 0.028) than did patients receiving LI alone.(ABSTRACT TRUNCATED AT 250 WORDS)
W V Vieweg; G R Yank; T L Steckler; M T Clayton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Psychiatric quarterly     Volume:  58     ISSN:  0033-2720     ISO Abbreviation:  Psychiatr Q     Publication Date:    1986-1987 Summer
Date Detail:
Created Date:  1987-05-20     Completed Date:  1987-05-20     Revised Date:  2006-07-19    
Medline Journal Info:
Nlm Unique ID:  0376465     Medline TA:  Psychiatr Q     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  135-43     Citation Subset:  IM    
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MeSH Terms
Age Factors
Carbamazepine / adverse effects*
Drug Therapy, Combination
Hospitals, Psychiatric
Hospitals, State
Hypothyroidism / chemically induced*
Lithium / adverse effects*
Middle Aged
Phenytoin / adverse effects*
Psychotic Disorders / complications,  drug therapy
Thyrotropin / blood
Thyrotropin-Releasing Hormone / diagnostic use
Thyroxine / blood
Triiodothyronine / blood
Reg. No./Substance:
24305-27-9/Thyrotropin-Releasing Hormone; 298-46-4/Carbamazepine; 57-41-0/Phenytoin; 6893-02-3/Triiodothyronine; 7439-93-2/Lithium; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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