Document Detail

Gradenigo's syndrome with lateral venous sinus thrombosis: successful conservative treatment.
MedLine Citation:
PMID:  19697060     Owner:  NLM     Status:  MEDLINE    
Gradenigo's syndrome (GS) is a rare disease characterised by the triad otitis media, pain in the region innervated by the first and the second division of trigeminal nerve and abducens nerve palsy. Septic sinus thrombosis is one of the most frequent and relevant complication of GS; it is often due to persistent damage and late diagnosis. Computed tomography (CT) scan and magnetic resonance imaging (MRI) allow the correct diagnosis in most cases. Surgical therapy may be necessary for a better and more rapid resolution of the disease. We report the case of a 4-year-old child that was admitted for facial nerve palsy and abducens nerve palsy subsequent to a 2-week persistent pain in the right ear. MRI showed infective acute process of the right mastoid and partial ipsilateral sinus thrombophlebitis. The child was treated with high-dose intravenous antibiotics and with oral anticoagulants. A complete resolution of symptoms and radiological alterations were observed within 7 weeks. In conclusion, lateral sinus thrombosis and Gradenigo's syndrome are rare but potential fatal complications of otitis media and mastoiditis. High-dose intravenous antibiotics and a low dose of anticoagulant can achieve a complete recovery without surgery.
Alessandra Scardapane; Marianna Del Torto; Manuela Nozzi; Concettina Elio; Luciana Breda; Francesco Chiarelli
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-08-21
Journal Detail:
Title:  European journal of pediatrics     Volume:  169     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-02-12     Completed Date:  2010-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  437-40     Citation Subset:  IM    
Department of Paediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini, 5, 66013, Chieti, Italy.
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MeSH Terms
Abducens Nerve Diseases / complications*,  drug therapy*
Administration, Oral
Anti-Bacterial Agents / therapeutic use
Anticoagulants / therapeutic use
Child, Preschool
Infusions, Intravenous
Otitis Media / complications*,  drug therapy*
Paralysis / complications,  drug therapy*
Sinus Thrombosis, Intracranial / complications*,  drug therapy*
Trigeminal Nerve Diseases / complications*,  drug therapy*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anticoagulants

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