Document Detail

Graded intestinal vascular obstruction: I. Description of an experimental shock model in the rat.
MedLine Citation:
PMID:  7389065     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to standardize a model allowing studies of mechanisms of importance for developing irreversible shock. The model should also be suitable for studying the effects of different modes of treatment. Graded obstruction of the intestine and its vascular supply in rats was induced with a hydrostatic pressure cuff. Three levels of obstruction pressure were used: 50, 100, and 120 cm water. Mortality increased from 0% in control groups to 75% in the highest pressure group. Increases in hematocrit occurred in all groups. Mucosal lesions, including total destruction of villi, were more severe in the two highest pressure groups, and the degree of mucosal lesion correlated with mortality. This shock model was developed to allow studies of factors of importance for survival. One such factor is the degree of mucosal lesion.
E Haglind; U Haglund; O Lundgren; M Romanus; T Scherstén
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulatory shock     Volume:  7     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1980  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-91     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Disease Models, Animal*
Intestinal Mucosa / pathology
Intestinal Obstruction / complications*,  mortality
Intestine, Small / blood supply
Shock / complications*,  mortality

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