Document Detail


Graded encoding of food odor value in the Drosophila brain.
MedLine Citation:
PMID:  24089477     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Odors are highly evocative, yet how and where in the brain odors derive meaning remains unknown. Our analysis of the Drosophila brain extends the role of a small number of hunger-sensing neurons to include food-odor value representation. In vivo two-photon calcium imaging shows the amplitude of food odor-evoked activity in neurons expressing Drosophila neuropeptide F (dNPF), the neuropeptide Y homolog, strongly correlates with food-odor attractiveness. Hunger elevates neural and behavioral responses to food odors only, although food odors that elicit attraction in the fed state also evoke heightened dNPF activity in fed flies. Inactivation of a subset of dNPF-expressing neurons or silencing dNPF receptors abolishes food-odor attractiveness, whereas genetically enhanced dNPF activity not only increases food-odor attractiveness but promotes attraction to aversive odors. Varying the amount of presented odor produces matching graded neural and behavioral curves, which can function to predict preference between odors. We thus demonstrate a possible motivationally scaled neural "value signal" accessible from uniquely identifiable cells.
Authors:
Jennifer Beshel; Yi Zhong
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-03     Completed Date:  2013-11-25     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15693-704     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Genetically Modified
Behavior, Animal / physiology
Brain / physiology*
Brain Mapping
Drosophila / physiology*
Food*
Motivation / physiology*
Odors*
Olfactory Pathways / physiology
Olfactory Perception / physiology*
Grant Support
ID/Acronym/Agency:
R01 DC005784/DC/NIDCD NIH HHS; R01 NS064331/NS/NINDS NIH HHS
Comments/Corrections

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