Document Detail


Gouty panniculitis with ulcerations in a patient with multiple organ dysfunctions.
MedLine Citation:
PMID:  25018887     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Gouty panniculitis is a rare manifestation of gout. Clinically, it is characterized by indurated subcutaneous nodules in nonjoint areas. Pathologically, typical characteristic gouty tophi can be seen in subcutaneous tissue. It is postulated that gouty panniculitis develops as a consequence of uric acid accumulation in the body and localized inflammatory changes in subcutaneous tissue. We report a case of a 46-year-old man with 20-year history of gout, who developed multiple subcutaneous nodules over the abdomen and right groin/thigh area over a 2-year period. After a recent episode of congestive heart failure and acute renal failure, the nodules increased in size and the overlying skin became erythematous and ulcerated. Pathologic examination demonstrated typical tophi in the dermis and subcutaneous tissue. A review of the literature yielded fifteen similar cases that had been previously reported. We conclude that gouty panniculitis may be a manifestation of undertreated gout and may be exacerbated by the deterioration of other systemic functions.
Authors:
Lu Wang; Crystal Rose; Paul Mellen; George Branam; Maria M Picken
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Publication Detail:
Type:  Journal Article     Date:  2014-06-15
Journal Detail:
Title:  Case reports in rheumatology     Volume:  2014     ISSN:  2090-6889     ISO Abbreviation:  Case Rep Rheumatol     Publication Date:  2014  
Date Detail:
Created Date:  2014-07-14     Completed Date:  2014-07-14     Revised Date:  2014-07-17    
Medline Journal Info:
Nlm Unique ID:  101585353     Medline TA:  Case Rep Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  320940     Citation Subset:  -    
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