Document Detail


Gout in the Hmong in the United States.
MedLine Citation:
PMID:  20808166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare characteristics of gout in Hmong patients versus whites, and examine if Hmong ethnicity is associated with risk of tophaceous gout.
METHODS: A retrospective chart review of Hmong and White patients with gout in a large health care system (Health Partners) in St. Paul, Minnesota, from January 2001 to March 2008, to compare clinical characteristics and risk factors for gout. Multivariable-adjusted hierarchical logistic regressions examined the association of Hmong ethnicity with risk of tophaceous gout, adjusting for age, sex, hypertension, diuretic use, and kidney function.
RESULTS: The analytic dataset consisted of 89 Hmong patients and 84 White controls, all of whom had ethnicity confirmed, an International Classification of Diseases, ninth revision code for gout and had at least 2 physician-documented diagnoses of gout. The Hmong group was younger (58.3 vs. 66.3 years, P = 0.04), had an earlier onset of symptoms (37.4 vs. 55.0 years, P < 0.001) and higher mean serum uric acid levels during follow-up (9.1 vs. 7.6 mg/dL, P < or = 0.001). Hmong had higher rates of tophaceous gout (31.5% vs. 10.7%, P = 0.001), including hand tophi (21.3% vs. 3.6%, P < 0.001). In multivariable analyses that adjusted for age, sex, hypertension, diuretic, use, and kidney function, Hmong ethnicity was significantly associated with risk of tophaceous gout, with odds ratio 4.3 (95% confidence interval: 1.5, 12.2).
CONCLUSION: Hmong patients have an earlier onset of gout symptoms. Hmong race is an independent risk factor for tophaceous gout. Future studies need to examine whether genetic or other comorbid factors predict this higher risk of more severe gout in Hmong.
Authors:
Salman Wahedduddin; Jasvinder A Singh; Kathleen A Culhane-Pera; Elie Gertner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  16     ISSN:  1536-7355     ISO Abbreviation:  J Clin Rheumatol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-12-16     Revised Date:  2013-12-19    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  262-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Allopurinol / therapeutic use
Asian Americans / ethnology*
European Continental Ancestry Group / ethnology
Female
Gout / drug therapy,  epidemiology*,  ethnology*
Gout Suppressants / therapeutic use
Humans
Male
Middle Aged
Prevalence
Retrospective Studies
Risk Factors
Severity of Illness Index
United States / epidemiology
Grant Support
ID/Acronym/Agency:
1 KL2 RR024151-01/RR/NCRR NIH HHS; KL2 RR024151/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Gout Suppressants; 63CZ7GJN5I/Allopurinol
Comments/Corrections

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