Document Detail

Gout in 2006: the perfect storm.
MedLine Citation:
PMID:  17121496     Owner:  NLM     Status:  MEDLINE    
Mechanistic and therapeutic advances in gout have been moving swiftly in the past decade. Clinically, the disease is changing in character. This review discusses several of the pertinent recent developments in understanding gout and in novel therapeutics for the disease. Subjects addressed include the role of URAT1-mediated renal proximal tubule epithelial cell urate anion reabsorption in hyperuricemia. We discuss the therapeutic limitations of allopurinol and uricosurics and the potential applications of novel xanthine oxidase inhibitors and of recombinant uricase preparations. Last, we summarize understanding of the central role of the early induced innate immune response in gouty inflammation, which has suggested the potential value of new strategies for treating gouty inflammation by targeting caspase-1 or IL-1beta.
Robert Terkeltaub
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Bulletin of the NYU hospital for joint diseases     Volume:  64     ISSN:  1936-9719     ISO Abbreviation:  -     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-23     Completed Date:  2007-04-10     Revised Date:  2007-05-31    
Medline Journal Info:
Nlm Unique ID:  101300541     Medline TA:  Bull NYU Hosp Jt Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  82-6     Citation Subset:  IM    
VAMC/UCSD, 3350La Jolla Village Drive, 111K, San Diego, California 92161, USA.
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MeSH Terms
Gout* / drug therapy,  epidemiology,  metabolism
Gout Suppressants / therapeutic use*
Morbidity / trends*
Uric Acid / antagonists & inhibitors,  metabolism*
World Health
Reg. No./Substance:
0/Gout Suppressants; 69-93-2/Uric Acid

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