Document Detail

Gout, hyperuricemia, and Parkinson's disease: a protective effect?
MedLine Citation:
PMID:  20425025     Owner:  NLM     Status:  MEDLINE    
Oxidative stress is potentially involved in the pathogenesis of Parkinson's disease (PD). Serum uric acid, because of its antioxidant effect, might prevent the development of this neurodegenerative disorder. Indeed, a number of epidemiologic studies have consistently reported a strong inverse association between serum uric acid and the risk of PD. The risk of PD is also lower among individuals with gout. In addition, suggestive evidence from clinical studies shows high levels of uric acid as a marker of better prognosis in PD. Future research should determine the mechanisms underlying this association. This, in turn, could be used in the development of new preventive strategies and treatments for PD.
Alvaro Alonso; Kelly A Sovell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current rheumatology reports     Volume:  12     ISSN:  1534-6307     ISO Abbreviation:  Curr Rheumatol Rep     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-28     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888970     Medline TA:  Curr Rheumatol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  IM    
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Minneapolis, MN 55454, USA.
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MeSH Terms
Biological Markers / metabolism
Clinical Trials as Topic
Gout / epidemiology,  metabolism*
Hyperuricemia / epidemiology,  metabolism*
Oxidative Stress
Parkinson Disease / epidemiology,  etiology,  metabolism*
Risk Factors
Uric Acid / metabolism
Reg. No./Substance:
0/Biological Markers; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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