| Gout, hyperuricemia, and Parkinson's disease: a protective effect? | |
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MedLine Citation:
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PMID: 20425025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative stress is potentially involved in the pathogenesis of Parkinson's disease (PD). Serum uric acid, because of its antioxidant effect, might prevent the development of this neurodegenerative disorder. Indeed, a number of epidemiologic studies have consistently reported a strong inverse association between serum uric acid and the risk of PD. The risk of PD is also lower among individuals with gout. In addition, suggestive evidence from clinical studies shows high levels of uric acid as a marker of better prognosis in PD. Future research should determine the mechanisms underlying this association. This, in turn, could be used in the development of new preventive strategies and treatments for PD. |
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Authors:
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Alvaro Alonso; Kelly A Sovell |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current rheumatology reports Volume: 12 ISSN: 1534-6307 ISO Abbreviation: Curr Rheumatol Rep Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-28 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888970 Medline TA: Curr Rheumatol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 149-55 Citation Subset: IM |
Affiliation:
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Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Minneapolis, MN 55454, USA. aalogut@alumni.unav.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / metabolism Clinical Trials as Topic Comorbidity Female Gout / epidemiology, metabolism* Humans Hyperuricemia / epidemiology, metabolism* Male Oxidative Stress Parkinson Disease / epidemiology, etiology, metabolism* Prognosis Risk Factors Uric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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