Document Detail


Gossypol in female fertility control: ovum implantation and early pregnancy inhibited in rats.
MedLine Citation:
PMID:  4010468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intramuscular administration of gossypol to normally cycling female rats induced an irregularity of the cyclic pattern for as long as the treatment was continued. Furthermore, administration of gossypol from days 0 (day of sperm-positive vaginal smear) to 8 of pregnancy prevented the normal maintenance of pregnancy. Serum values of progesterone and estradiol 17 beta in gossypol-treated normally cycling and pregnant rats were significantly lower than the control levels. The supplement of a combination of exogenous progesterone and estradiol 17 beta eliminated the inhibitory effects of gossypol on ovum implantation and the maintenance of pregnancy. Our results indicate that gossypol may have some usefulness in female fertility control.
Authors:
Y C Lin; T Fukaya; Y Rikihisa; A Walton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  37     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-21     Completed Date:  1985-08-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  39-47     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Contraceptive Agents, Female / pharmacology*
Embryo Implantation / drug effects*
Estradiol / blood
Estrus / drug effects
Female
Gossypol / pharmacology*
Pregnancy
Progesterone / blood
Rats
Rats, Inbred Strains
Grant Support
ID/Acronym/Agency:
HD 16627/HD/NICHD NIH HHS; HD 16883/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Contraceptive Agents, Female; 303-45-7/Gossypol; 50-28-2/Estradiol; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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