Document Detail


Gossypium herbaceam extracts attenuate ibotenic acid-induced excitotoxicity in rat hippocampus.
MedLine Citation:
PMID:  19221423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Excitotoxicity is one of the most extensively studied processes of neuronal death and plays an important role in Alzheimer's disease. In the present study, the protective effects of Gossypium herbaceam extracts (GHE) on learning and memory impairment induced by excitatory neurotoxin ibotenic acid were examined in vivo using Morris water maze. Furthermore, neuroprotective effects of GHE were investigated with methods of immunohistochemistry and biochemistry. Our data showed that oral administration with GHE at the doses of 35, 70 and 140 mg/kg exerted an improved effect on the learning and memory impairment in rats induced by intracerebral injection of ibotenic acid. To confirm the precise mechanism of memory improvement by presence of GHE, we further investigated the potential protection on the hippocampus. Our findings suggest that GHE afforded a beneficial inhibition on pro-apoptosis proteins expression following ibotenic acid. Additionally, calcium pump activity and calbindin-D28k expression were dramatically increased after GHE treatment, implicating that the modulation of calcium homeostasis could be involved in the mechanism underlying neuroprotection of GHE against ibotenic acid-induced excitotoxicity. These data suggested that GHE could be a potential agent for preventing or retarding the development or progression of Alzheimer's disease.
Authors:
Chao Ji; Qing Li; HajiAkber Aisa; Nan Yang; Yi-Long Dong; Yan-Yong Liu; Tao Wang; Qiang Hao; Hai-Bo Zhu; Ping-Ping Zuo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  16     ISSN:  1387-2877     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2009  
Date Detail:
Created Date:  2009-02-17     Completed Date:  2009-06-17     Revised Date:  2010-10-22    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  331-9     Citation Subset:  IM    
Affiliation:
School of Basic Medicine, Peking Union Medical College & Institute of Basic Medical Science, Chinese Academy of Medical Sciences, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / drug effects,  metabolism
Calcium-Binding Protein, Vitamin D-Dependent / metabolism
Calcium-Transporting ATPases / metabolism
Caspase 3 / metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Escape Reaction / drug effects
Excitatory Amino Acid Agonists / toxicity
Gossypium / chemistry*
Hippocampus / drug effects,  pathology,  physiopathology*
Ibotenic Acid / toxicity
Injections, Intraventricular / methods
Male
Maze Learning / drug effects
Neurotoxicity Syndromes / drug therapy*,  etiology,  metabolism,  physiopathology
Phytotherapy / methods*
Plant Preparations / therapeutic use*
Proto-Oncogene Proteins c-bcl-2 / metabolism
Rats
Rats, Sprague-Dawley
Time Factors
bcl-2-Associated X Protein / metabolism
Chemical
Reg. No./Substance:
0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Excitatory Amino Acid Agonists; 0/Plant Preparations; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein; 0/calbindin; 2552-55-8/Ibotenic Acid; EC 3.4.22.-/Caspase 3; EC 3.6.1.8/Calcium-Transporting ATPases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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