| Gossypium herbaceam extracts attenuate ibotenic acid-induced excitotoxicity in rat hippocampus. | |
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MedLine Citation:
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PMID: 19221423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Excitotoxicity is one of the most extensively studied processes of neuronal death and plays an important role in Alzheimer's disease. In the present study, the protective effects of Gossypium herbaceam extracts (GHE) on learning and memory impairment induced by excitatory neurotoxin ibotenic acid were examined in vivo using Morris water maze. Furthermore, neuroprotective effects of GHE were investigated with methods of immunohistochemistry and biochemistry. Our data showed that oral administration with GHE at the doses of 35, 70 and 140 mg/kg exerted an improved effect on the learning and memory impairment in rats induced by intracerebral injection of ibotenic acid. To confirm the precise mechanism of memory improvement by presence of GHE, we further investigated the potential protection on the hippocampus. Our findings suggest that GHE afforded a beneficial inhibition on pro-apoptosis proteins expression following ibotenic acid. Additionally, calcium pump activity and calbindin-D28k expression were dramatically increased after GHE treatment, implicating that the modulation of calcium homeostasis could be involved in the mechanism underlying neuroprotection of GHE against ibotenic acid-induced excitotoxicity. These data suggested that GHE could be a potential agent for preventing or retarding the development or progression of Alzheimer's disease. |
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Authors:
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Chao Ji; Qing Li; HajiAkber Aisa; Nan Yang; Yi-Long Dong; Yan-Yong Liu; Tao Wang; Qiang Hao; Hai-Bo Zhu; Ping-Ping Zuo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of Alzheimer's disease : JAD Volume: 16 ISSN: 1387-2877 ISO Abbreviation: J. Alzheimers Dis. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-02-17 Completed Date: 2009-06-17 Revised Date: 2010-10-22 |
Medline Journal Info:
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Nlm Unique ID: 9814863 Medline TA: J Alzheimers Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 331-9 Citation Subset: IM |
Affiliation:
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School of Basic Medicine, Peking Union Medical College & Institute of Basic Medical Science, Chinese Academy of Medical Sciences, Beijing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, metabolism Calcium-Binding Protein, Vitamin D-Dependent / metabolism Calcium-Transporting ATPases / metabolism Caspase 3 / metabolism Disease Models, Animal Dose-Response Relationship, Drug Escape Reaction / drug effects Excitatory Amino Acid Agonists / toxicity Gossypium / chemistry* Hippocampus / drug effects, pathology, physiopathology* Ibotenic Acid / toxicity Injections, Intraventricular / methods Male Maze Learning / drug effects Neurotoxicity Syndromes / drug therapy*, etiology, metabolism, physiopathology Phytotherapy / methods* Plant Preparations / therapeutic use* Proto-Oncogene Proteins c-bcl-2 / metabolism Rats Rats, Sprague-Dawley Time Factors bcl-2-Associated X Protein / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Excitatory Amino Acid Agonists; 0/Plant Preparations; 0/Proto-Oncogene Proteins c-bcl-2; 0/bcl-2-Associated X Protein; 0/calbindin; 2552-55-8/Ibotenic Acid; EC 3.4.22.-/Caspase 3; EC 3.6.1.8/Calcium-Transporting ATPases |
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