Document Detail


Gorlin formulas for aortic regurgitant and mitral regurgitant orifice areas: experimental studies.
MedLine Citation:
PMID:  16252567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: The measurement of aortic regurgitant and mitral regurgitant orifice areas has recently been pioneered. The present study tried to establish Gorlin formulas for aortic regurgitant and mitral regurgitant orifice areas for evaluating the severity of aortic regurgitation and mitral regurgitation. METHODS: Seventeen stable hemodynamic states for mitral regurgitation and 22 for aortic regurgitation were studied in sheep. Aortic regurgitant and mitral regurgitant orifice areas were determined by dividing regurgitant volume per second by the time integrals of the continuous aortic regurgitant and mitral regurgitant wave velocities. Aortic regurgitant and mitral regurgitant orifice areas calculated by the formulas using echocardiographic data were compared with other measurements by electromagnetic flowmeters. RESULTS: The Gorlin formulas were aortic regurgitant orifice area = per second valve flow/ 50.7 square root mean pressure gradient, and mitral regurgitant orifice area = per second valve flow/ 27.5 square root mean pressure gradient. Simple linear analysis between aortic regurgitant fractions, regurgitant volume per beat and peak aortic regurgitant flow rates, and aortic regurgitant orifice areas derived from the formula showed moderately good relationships (r = 0.73, 0.81 and 0.83). Mitral regurgitant orifice areas calculated by the formula also correlated with mitral regurgitant fractions, regurgitant volume per beat and peak mitral regurgitant flow rates (r = 0.86, 0.92 and 0.74). CONCLUSIONS: The Gorlin formulas for aortic regurgitant and mitral regurgitant orifice area may provide an index for evaluating the severity of regurgitation.
Authors:
Masahide Chikada; Takahiro Shiota; Michael Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiology     Volume:  46     ISSN:  0914-5087     ISO Abbreviation:  J Cardiol     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-28     Completed Date:  2005-11-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, St. Marianna University, School of Medicine, Kawasaki. chikada-circ@umin.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Aortic Valve Insufficiency / physiopathology*,  ultrasonography*
Blood Flow Velocity
Echocardiography, Doppler
Electromagnetic Fields
Hemodynamics
Mitral Valve Insufficiency / physiopathology*,  ultrasonography*
Observer Variation
Regional Blood Flow
Rheology / methods
Severity of Illness Index
Sheep

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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