Document Detail


Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development.
MedLine Citation:
PMID:  7555726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Goosecoid (gsc) is an evolutionarily conserved homeobox gene expressed in the gastrula organizer region of a variety of vertebrate embryos, including zebrafish, Xenopus, chicken and mouse. To understand the role of gsc during mouse embryogenesis, we generated gsc-null mice by gene targeting in embryonic stem cells. Surprisingly, gsc-null embryos gastrulated and formed the primary body axes; gsc-null mice were born alive but died soon after birth with numerous craniofacial defects. In addition, rib fusions and sternum abnormalities were detected that varied depending upon the genetic background. Transplantation experiments suggest that the ovary does not provide gsc function to rescue gastrulation defects. These results demonstrate that gsc is not essential for organizer activity in the mouse but is required later during embryogenesis for craniofacial and rib cage development.
Authors:
J A Rivera-Pérez; M Mallo; M Gendron-Maguire; T Gridley; R R Behringer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  121     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-11-08     Completed Date:  1995-11-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  3005-12     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA-Binding Proteins / genetics*
Facial Bones / embryology*
Female
Fetal Death
Gastrula / physiology*
Gene Expression
Gene Targeting
Genes, Homeobox*
Goosecoid Protein
Homeodomain Proteins*
Mice
Mice, Mutant Strains
Morphogenesis / genetics
Phenotype
Repressor Proteins*
Ribs / embryology*
Skull / embryology*
Transcription Factors*
Grant Support
ID/Acronym/Agency:
HD31155/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Goosecoid Protein; 0/Gsc protein, mouse; 0/Homeodomain Proteins; 0/Repressor Proteins; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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