Document Detail

Goodpasture-like syndrome induced by D-penicillamine in a patient with systemic sclerosis: report and review of the literature.
MedLine Citation:
PMID:  12858467     Owner:  NLM     Status:  MEDLINE    
We report a case of Goodpasture-like syndrome developing in a patient who was treated with D-penicillamine for the diffuse form of systemic sclerosis. This unusual pulmonary-renal syndrome has been described on rare occasions in patients receiving D-penicillamine. This complication appeared to be uniformly fatal unless treated with aggressive immunotherapy. We review the cases reported to date in the literature and describe the clinical characteristics, therapy, and outcome of this group of patients.
Chris T Derk; Sergio A Jimenez
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  30     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-14     Completed Date:  2003-10-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1616-20     Citation Subset:  IM    
Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107-5541, USA.
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MeSH Terms
Anti-Glomerular Basement Membrane Disease / chemically induced*,  pathology
Antirheumatic Agents / adverse effects*
Fatal Outcome
Glomerulonephritis / chemically induced,  pathology
Hemorrhage / chemically induced,  pathology
Lung Diseases / chemically induced,  pathology
Penicillamine / adverse effects*
Radiography, Thoracic
Scleroderma, Systemic / complications,  drug therapy*
Grant Support
Reg. No./Substance:
0/Antirheumatic Agents; 52-67-5/Penicillamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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