Document Detail

Gonadotropin-releasing hormone antagonist use in controlled ovarian stimulation and intrauterine insemination cycles in women with polycystic ovary syndrome.
MedLine Citation:
PMID:  19200979     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To observe the effects of ganirelix on controlled ovarian stimulation and intrauterine insemination (COS/IUI) cycles in women with polycystic ovary syndrome (PCOS). DESIGN: Prospective, randomized, controlled clinical study. SETTING: An academic clinical research center. PATIENT(S): Women with PCOS and anovulatory infertility undergoing COS/IUI. INTERVENTION(S): Recombinant FSH therapy was started on day 3. In women assigned to the control group (n = 47), treatment was continued up to the day of hCG administration. In patients assigned to receive GnRH antagonist (n = 42), ganirelix was added when the leading follicle was > or =14 mm. MAIN OUTCOME MEASURE(S): Pregnancy rates, serum E(2), P, and LH levels, and follicle numbers at hCG day, prevalence of premature luteinization, and cost of stimulation. RESULT(S): Serum E(2), P, and LH levels were significantly lower in the ganirelix group. Although premature luteinization and cycle cancellation was encountered less in the ganirelix group, the pregnancy rates per cycle were similar (15.4% vs. 10.7%). Patients would pay 6,153 dollars more for each pregnancy when using ganirelix. CONCLUSION(S): Gonadotropin-releasing hormone antagonist resulted in more monofollicular development, less premature luteinization, and less cycle cancellation in IUI cycles of patients with PCOS; however, the cost of stimulation increased without an improvement in pregnancy rates.
Devrim Ertunc; Ekrem C Tok; Aysun Savas; Ilay Ozturk; Saffet Dilek
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2009-02-06
Journal Detail:
Title:  Fertility and sterility     Volume:  93     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1179-84     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Department of Obstetrics and Gynecology, School of Medicine, Mersin University, Mersin, Turkey.
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MeSH Terms
Gonadotropin-Releasing Hormone / analogs & derivatives*,  antagonists & inhibitors*,  blood,  pharmacology,  therapeutic use
Hormone Antagonists / pharmacology,  therapeutic use
Infertility, Female / blood,  drug therapy,  etiology
Insemination, Artificial, Homologous / methods*
Ovulation Induction / methods*
Polycystic Ovary Syndrome / blood,  complications,  drug therapy*
Prospective Studies
Young Adult
Reg. No./Substance:
0/Hormone Antagonists; 123246-29-7/ganirelix; 33515-09-2/Gonadotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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