Document Detail


Gonadotropin-releasing hormone analogues for the treatment of endometriosis: long-term follow-up.
MedLine Citation:
PMID:  8458449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the long-term recurrence rate of endometriosis after treatment with gonadotropin-releasing hormone analogues (GnRH-a). DESIGN: A historical prospective study. SETTING: Royal Free Hospital, London, a tertiary referral center for the treatment of endometriosis. PATIENTS: One hundred thirty patients with endometriosis had treatment with GnRH-a buserelin acetate, goserelin, and nafarelin acetate between the years 1985 and 1987. Patients no longer being followed in the gynecology clinic were sent a questionnaire to determine their state of health. Information was also requested from the patient's general practitioner. MAIN OUTCOME MEASURES: The cumulative recurrence rate for the fifth year after treatment ended was 53.4%. RESULTS: Patients with a higher disease stage at the outset were more likely to experience recurrence and experience it earlier than patients with minimal disease. Fifth-year recurrence rates were 36.9% for minimal disease and 74.4% for severe disease. The change in endometriosis stage classification scores at second-look laparoscopy for those patients whose disease recurred after treatment was not significantly different from those whose disease did not recur during the study period. CONCLUSIONS: Patients with endometriosis treated with GnRH-a are highly likely to suffer a recurrence of their disease, particularly if their disease is severe at the outset.
Authors:
K G Waller; R W Shaw
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Fertility and sterility     Volume:  59     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-23     Completed Date:  1993-04-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  511-5     Citation Subset:  IM    
Affiliation:
Academic Department of Obstetrics and Gynaecology, Royal Free Hospital, London, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Buserelin / therapeutic use*
Endometriosis / drug therapy*
Female
Follow-Up Studies
Goserelin / therapeutic use*
Humans
Middle Aged
Nafarelin / therapeutic use*
Prospective Studies
Recurrence
Chemical
Reg. No./Substance:
57982-77-1/Buserelin; 65807-02-5/Goserelin; 76932-56-4/Nafarelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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