| Gonadotropin-releasing hormone agonist to induce final oocyte maturation prevents the development of ovarian hyperstimulation syndrome in high-risk patients and leads to improved clinical outcomes compared with coasting. | |
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MedLine Citation:
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PMID: 20074722 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ninety-four women undergoing IVF with peak E2 level>4000 pg/mL received leuprolide acetate (LA) trigger (LA trigger group) or had gonadotropins withheld for one or more days (coasting group) followed by hCG trigger, unless cycle cancellation occurred. There were no cases of ovarian hyperstimulation syndrome in either group, and the LA trigger group had significantly more oocytes retrieved (26.9+/-9.5 vs. 17.7+/-9.3) P<0.001, more normally fertilized oocytes (15.0+/-7.8 vs. 10.3+/-6.3) P=0.01, and higher clinical and ongoing pregnancy rates than the coasting group (52.5% vs. 27.2%; 49.2% vs. 24.2%, P=0.02 for both comparisons, respectively). |
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Authors:
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Andrea J DiLuigi; Lawrence Engmann; David W Schmidt; Donald B Maier; John C Nulsen; Claudio A Benadiva |
Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2010-01-13 |
Journal Detail:
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Title: Fertility and sterility Volume: 94 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2010-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1111-4 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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The Center for Advanced Reproductive Services, Division of Reproductive Endocrinology and Infertility, University of Connecticut Health Center, Farmington, Connecticut 06030-6224, USA. diluigi@uchc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Drug Administration Schedule Estradiol / blood Female Fertility Agents, Female / administration & dosage, adverse effects, pharmacology Gonadotropin-Releasing Hormone / agonists Humans Leuprolide / administration & dosage*, adverse effects, pharmacology* Oocytes / drug effects*, physiology Oogenesis / drug effects Ovarian Hyperstimulation Syndrome / blood, etiology, prevention & control* Pregnancy Pregnancy Rate Retrospective Studies Risk Factors Treatment Outcome Withholding Treatment* |
| Chemical | |
Reg. No./Substance:
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0/Fertility Agents, Female; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 53714-56-0/Leuprolide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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