Document Detail

Gonadotropin-releasing hormone agonist or human chorionic gonadotropin for final oocyte maturation in an oocyte donor program.
MedLine Citation:
PMID:  19171336     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare leuprolide acetate to hCG as the trigger for final oocyte maturation in oocyte donor cycles.
DESIGN: Retrospective review.
SETTING: Academic IVF donor program.
PATIENT(S): Thirty-two healthy oocyte donors aged 21-33 years with adequate ovarian reserve.
INTERVENTION(S): Donors were down-regulated with cetrorelix and received either leuprolide acetate (n = 12) or hCG (n = 20) for final oocyte maturation.
MAIN OUTCOME MEASURE(S): Embryo number, embryo quality, fertilization, implantation, clinical pregnancy, and ovarian hyperstimulation syndrome rates.
RESULT(S): The numbers of total oocytes (23 vs. 15), mature (metaphase II) oocytes (22 vs. 13), embryos (15 vs. 10), and cryopreserved embryos (12 vs. 6) per treatment cycle were significantly greater in the leuprolide arm than in the hCG arm. Fertilization rates (73% vs. 78%), implantation rates (30% vs. 29%), and clinical pregnancy rates (40% vs. 50%) were not statistically different between the arms. There were no cases of ovarian hyperstimulation syndrome.
CONCLUSION(S): Leuprolide acetate-triggered oocyte donor cycles yielded similar fertilization, implantation, and clinical pregnancy rates to hCG-triggered cycles.
Teresa M Erb; Wendy Vitek; Anthony N G Wakim
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Publication Detail:
Type:  Journal Article     Date:  2009-01-26
Journal Detail:
Title:  Fertility and sterility     Volume:  93     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-02-24     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  374-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Reproductive Endocrinology and Infertility, Magee Women's Hospital, Pittsburgh, Pennsylvania 15213, USA.
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MeSH Terms
Chorionic Gonadotropin / therapeutic use*
Estradiol / blood
Follicle Stimulating Hormone / blood
Gonadotropin-Releasing Hormone / agonists*,  analogs & derivatives*,  therapeutic use
Hormone Antagonists / therapeutic use
Intercellular Signaling Peptides and Proteins / pharmacology
Leuprolide / therapeutic use*
Oocyte Donation
Oocytes / drug effects,  physiology*
Ovarian Follicle / cytology,  drug effects
Ovulation Induction
Retrospective Studies
Young Adult
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Hormone Antagonists; 0/Intercellular Signaling Peptides and Proteins; 0/intraovarian peptides; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 53714-56-0/Leuprolide; 9002-68-0/Follicle Stimulating Hormone; OON1HFZ4BA/cetrorelix

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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