| Gonadotropin-releasing hormone agonist or human chorionic gonadotropin for final oocyte maturation in an oocyte donor program. | |
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MedLine Citation:
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PMID: 19171336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare leuprolide acetate to hCG as the trigger for final oocyte maturation in oocyte donor cycles. DESIGN: Retrospective review. SETTING: Academic IVF donor program. PATIENT(S): Thirty-two healthy oocyte donors aged 21-33 years with adequate ovarian reserve. INTERVENTION(S): Donors were down-regulated with cetrorelix and received either leuprolide acetate (n = 12) or hCG (n = 20) for final oocyte maturation. MAIN OUTCOME MEASURE(S): Embryo number, embryo quality, fertilization, implantation, clinical pregnancy, and ovarian hyperstimulation syndrome rates. RESULT(S): The numbers of total oocytes (23 vs. 15), mature (metaphase II) oocytes (22 vs. 13), embryos (15 vs. 10), and cryopreserved embryos (12 vs. 6) per treatment cycle were significantly greater in the leuprolide arm than in the hCG arm. Fertilization rates (73% vs. 78%), implantation rates (30% vs. 29%), and clinical pregnancy rates (40% vs. 50%) were not statistically different between the arms. There were no cases of ovarian hyperstimulation syndrome. CONCLUSION(S): Leuprolide acetate-triggered oocyte donor cycles yielded similar fertilization, implantation, and clinical pregnancy rates to hCG-triggered cycles. |
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Authors:
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Teresa M Erb; Wendy Vitek; Anthony N G Wakim |
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Publication Detail:
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Type: Journal Article Date: 2009-01-26 |
Journal Detail:
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Title: Fertility and sterility Volume: 93 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-28 Completed Date: 2010-02-24 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 374-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Reproductive Endocrinology and Infertility, Magee Women's Hospital, Pittsburgh, Pennsylvania 15213, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin / therapeutic use* Estradiol / blood Female Follicle Stimulating Hormone / blood Gonadotropin-Releasing Hormone / agonists*, analogs & derivatives*, therapeutic use Hormone Antagonists / therapeutic use Humans Intercellular Signaling Peptides and Proteins / pharmacology Leuprolide / therapeutic use* Oocyte Donation Oocytes / drug effects, physiology* Ovarian Follicle / cytology, drug effects Ovulation Induction Pregnancy Retrospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Hormone Antagonists; 0/Intercellular Signaling Peptides and Proteins; 0/intraovarian peptides; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 53714-56-0/Leuprolide; 9002-68-0/Follicle Stimulating Hormone; OON1HFZ4BA/cetrorelix |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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