Document Detail

Gonadotropin-releasing hormone agonist combined with a reduced dose of human chorionic gonadotropin for final oocyte maturation in fresh autologous cycles of in vitro fertilization.
MedLine Citation:
PMID:  17981269     Owner:  NLM     Status:  MEDLINE    
Acceptable rates of fertilization, implantation, clinical pregnancy, ongoing pregnancy, and early pregnancy loss were achieved in high responders after triggering final oocyte maturation with a combination of leuprolide acetate and hCG (1,000 to 2,500 IU). These findings, along with the absence of ovarian hyperstimulation syndrome, suggest that this dual trigger is safe and effective for oocyte maturation in patients with significant risk factors for ovarian hyperstimulation syndrome.
Bruce S Shapiro; Said T Daneshmand; Forest C Garner; Martha Aguirre; Shyni Thomas
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Publication Detail:
Type:  Journal Article     Date:  2007-11-05
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-01     Completed Date:  2008-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  231-3     Citation Subset:  IM    
Fertility Center of Las Vegas, 8851 West Sahara Avenue, Suite 100, Las Vegas, Nevada 89117, USA.
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MeSH Terms
Abortion, Spontaneous / chemically induced,  prevention & control
Chorionic Gonadotropin / administration & dosage*,  adverse effects
Drug Administration Schedule
Embryo Implantation
Embryo Transfer
Fertility Agents, Female / administration & dosage*,  adverse effects
Gonadotropin-Releasing Hormone / antagonists & inhibitors*
Hormone Antagonists / administration & dosage*,  adverse effects
Infertility / therapy*
Leuprolide / administration & dosage*,  adverse effects
Oocyte Retrieval
Ovarian Hyperstimulation Syndrome / chemically induced,  prevention & control*
Ovulation Induction / adverse effects,  methods*
Pilot Projects
Pregnancy Rate
Retrospective Studies
Sperm Injections, Intracytoplasmic
Treatment Outcome
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Fertility Agents, Female; 0/Hormone Antagonists; 33515-09-2/Gonadotropin-Releasing Hormone; 53714-56-0/Leuprolide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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