Document Detail


Gonadectomy and androgen replacement alter cardiac performance in conscious adult male rats.
MedLine Citation:
PMID:  16303636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gender disparities in cardiac function have been described. Yet the extent to which gender related differences in cardiac performance are due to the presence of sex-specific biological factors are unclear. We used a longitudinal study aimed at examining whether castration and androgen replacement affects cardiac performance in conscious adult male rats. Adult male rats were implanted with Piezoelectric transit-time gauges and radio telemetry devices to measure regional myocardial segment length and hemodynamic variables before and after castration and after androgen replacement. Androgen withdrawal accelerated average heart rates by 7% (p=0.010). Heart rate was lowered to intact values when androgens were restored to normal physiological levels (p=0.004). Mean arterial pressure was not affected by androgen deprivation and androgen replacement. However, androgen withdrawal produced a 40% decrease in the velocity of circumferential shortening and a 46% reduction in the rate of myocardial relaxation. Androgen supplementation completely restored contractile function. These results provide the first evidence that androgen withdrawal and androgen replacement produces dramatic alterations on cardiac performance in conscious animals and demonstrates the significance of androgens as a cardio-regulatory hormone in males. Sex steroids are likely contributors to gender-related differences in cardiac function.
Authors:
Kish L Golden; Heidi L Collins; Alfred M Loka; Stephen E Dicarlo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  27     ISSN:  1064-1963     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-23     Completed Date:  2006-02-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  593-604     Citation Subset:  IM    
Affiliation:
Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
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MeSH Terms
Descriptor/Qualifier:
Androgens / pharmacology*
Animals
Castration*
Consciousness
Heart / drug effects*,  physiology*
Heart Rate / drug effects,  physiology
Hemodynamics / drug effects*,  physiology*
Male
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
K01 HL67713/HL/NHLBI NIH HHS; K01HL04356/HL/NHLBI NIH HHS; R01 HL74122/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Androgens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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