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Gonadal steroids modulate Fas-induced apoptosis of lactotropes and somatotropes.
MedLine Citation:
PMID:  21069582     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We have previously reported that Fas activation induces apoptosis of anterior pituitary cells from rats at proestrus but not at diestrus and in an estrogen-dependent manner. In this study, we evaluated the effect of Fas activation on apoptosis of lactotropes and somatotropes during the estrous cycle and explored the action of gonadal steroids on Fas-induced apoptosis. Also, we studied whether changes in Fas expression are involved in the apoptotic response of anterior pituitary cells. Fas activation increased the percentage of TUNEL-positive lactotropes and somatotropes at proestrus but not at diestrus. FasL triggered apoptosis of somatotropes only when cells from ovariectomized rats were cultured in the presence of 17 β-estradiol (E2). Progesterone (P4) blocked the apoptotic action of the Fas/FasL system in lactotropes and somatotropes incubated with E2. Both E2 and P4 increased the percentage of cells expressing Fas at the cell membrane. Our results show that Fas activation induces apoptosis of lactotropes and somatotropes at proestrus but not at diestrus. Gonadal steroids may be involved in the apoptotic response of lactotropes and somatotropes, suggesting that Fas activation is implicated in the renewal of these pituitary subpopulations during the estrous cycle. The effect of gonadal steroids on Fas expression may be only partially involved in regulation of the Fas/FasL apoptotic pathway in the anterior pituitary gland.
Authors:
Gabriela Jaita; Sandra Zárate; Luciana Ferrari; Daniela Radl; Jimena Ferraris; Guadalupe Eijo; Verónica Zaldivar; Daniel Pisera; Adriana Seilicovich
Publication Detail:
Type:  Journal Article     Date:  2010-11-11
Journal Detail:
Title:  Endocrine     Volume:  39     ISSN:  1559-0100     ISO Abbreviation:  Endocrine     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21-7     Citation Subset:  IM    
Affiliation:
Facultad de Medicina, Instituto de Investigaciones en Reproducción, Universidad de Buenos Aires, Paraguay 2155, piso 10, ABG1121, Buenos Aires, Argentina.
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