Document Detail

Gonadal status and physical performance in older men.
MedLine Citation:
PMID:  20937007     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the relationship between gonadal status and objective measures and determinants of physical performance in older men and their determinants.
METHODS: The study included 455 ≥ 65 year older men of InCHIANTI study, Italy, with complete data on testosterone levels, hand grip strength, cross-sectional muscle area (CSMA), short physical performance battery (SPPB). Linear models were used to test the relationship between gonadal status and determinants of physical performance.
RESULTS: Three different groups of older men were created: (1) severely hypogonadal (N=23), total testosterone levels ≤ 230 ng /dl; (2) moderately hypogonadal (N=88), total testosterone >230 and < 350 ng/dl) and (3) eugonadal (N=344), testosterone levels ≥ 350 ng/dl. With increased severity of hypogonadal status, participants were significantly older while their BMI was substantially similar. In the age and BMI adjusted analysis, there was a significant difference in haemoglobin levels, hand grip strength and SPPB score (p for trend < 0.001) among three groups, with severely hypogonadal men having lower values of haemoglobin, muscle strength and physical performance. We found no association between testosterone group assignment and calf muscle mass and 4 m walking speed. In the multivariate analysis grip strength (p for trend = 0.004) and haemoglobin (p for trend < 0.0001) but not SPPB and other determinants of physical performance were significantly different between the three groups.
CONCLUSIONS: In older men, gonadal status is independently associated with some determinants (haemoglobin and muscle strength) of physical performance.
Marcello Maggio; Gian Paolo Ceda; Fulvio Lauretani; Stefania Bandinelli; Earl Jeffrey Metter; Jack M Guralnik; Shehzad Basaria; Chiara Cattabiani; Michele Luci; Elisabetta Dall'Aglio; Alessandro Vignali; Riccardo Volpi; Giorgio Valenti; Luigi Ferrucci
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2010-10-12
Journal Detail:
Title:  The aging male : the official journal of the International Society for the Study of the Aging Male     Volume:  14     ISSN:  1473-0790     ISO Abbreviation:  Aging Male     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-04     Completed Date:  2011-05-24     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9808210     Medline TA:  Aging Male     Country:  England    
Other Details:
Languages:  eng     Pagination:  42-7     Citation Subset:  IM    
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Italy.
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MeSH Terms
Age Factors
Androgens / blood*
Exercise Test
Health Status
Health Status Indicators
Hemoglobins / analysis
Hypogonadism / epidemiology*
Inflammation / blood
Interleukin-6 / analysis
Italy / epidemiology
Linear Models
Men's Health*
Motor Activity / physiology*
Muscle Strength
Muscle, Skeletal / physiology
Reference Values
Task Performance and Analysis
Testosterone / blood*
Grant Support
263 MD821336/MD/NIMHD NIH HHS; 263 MD9164 13/MD/NIMHD NIH HHS; N01-AG-821336/AG/NIA NIH HHS; N01-AG-916413/AG/NIA NIH HHS
Reg. No./Substance:
0/Androgens; 0/Hemoglobins; 0/Interleukin-6; 58-22-0/Testosterone

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