Document Detail

Gonadal dysgenesis and gynecologic cancer.
MedLine Citation:
PMID:  20664451     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Gonadal dysgenesis encompasses a variety of sexual differentiation disorders. Within this population of patients, there is an increased risk of gonadal tumor formation. CASES: In this case series of three patients, two with Swyer's syndrome (complete gonadal dysgenesis) and one with mosaic Turner's syndrome, three separate histologic subtypes of tumors were identified: dysgerminoma, seminoma, and gonadoblastoma. The patients with dysgerminoma and seminoma had regular menses and were without recurrent disease. We recommend that the patient with gonadoblastoma start on hormone therapy. CONCLUSION: Once the diagnosis of gonadal dysgenesis is made, prophylactic gonadectomy should be performed owing to the probability of malignant transformation. These patients illustrate the potential different presentations with gonadal dysgenesis and the importance of complete evaluation of patients with primary amenorrhea.
Amy L Jonson; Melissa A Geller; Elizabeth L Dickson
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  116 Suppl 2     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  550-2     Citation Subset:  AIM; IM    
Division of Gynecologic Oncology, University of Minnesota Department of Obstetrics, Gynecology, Women's Health, Minneapolis, Minnesota, USA.
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MeSH Terms
Abdominal Neoplasms / etiology
Amenorrhea / etiology
Dysgerminoma / etiology,  pathology*,  surgery
Gonadal Dysgenesis / complications*
Gonadal Dysgenesis, 46,XY / complications
Gonadoblastoma / etiology,  pathology*,  surgery
Ovarian Neoplasms / etiology,  pathology*,  surgery
Seminoma / etiology,  pathology*,  surgery
Turner Syndrome / complications
Young Adult

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