Document Detail


Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma.
MedLine Citation:
PMID:  20876776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: Golgi protein 73 (GP73) as a potential serum marker for hepatocellular carcinoma (HCC) has not been validated in large cohort studies. Furthermore, its significance in the assessment of tumour recurrence after HCC resection remains unknown. The aim of this study was to determine the value of serum GP73 in the diagnosis of HCC.
METHODS: Serum GP73 and alpha-fetoprotein (AFP) were compared in a total of 4217 human subjects in this multicentre study, including 1690 healthy adults, 337 hepatitis B virus (HBV) carriers, 512 patients with cirrhosis, 789 patients with HCC, 61 patients with other malignant liver lesions, 206 patients with benign liver lesions and 622 patients with 14 different kinds of non-liver cancers. The main outcome measures were the specificity and sensitivity of GP73 in patients at risk for the development of HCC.
RESULTS: Using 8.5 relative units as a cut-off value, the sensitivity and specificity of serum GP73 for HCC were 74.6% (95% CI 71.5% to 77.6%) and 97.4% (95% CI 96.8 to 98.3%), compared with 58.2% (95% CI 55.2% to 62.1%) and 85.3% (95% CI 83.4% to 88.1%) for AFP (p<0.001) using 35 ng/ml as a cut-off value. The GP73 level was significantly increased in patients with HCC compared with healthy controls (14.7 vs 1.2, p<0.001). Although GP73 levels in HBV carriers (2.9) and patients with cirrhosis (4.7) were somewhat elevated, they were much lower than that in patients with HCC (p<0.001). GP73 decreased following surgical resection of HCC lesions and increased with tumour recurrence. Fourteen types of non-liver cancers were analysed; all the benign and other malignant liver lesions had moderate elevations of GP73, albeit at a much lower level than in HCC.
CONCLUSIONS: GP73 is an accurate serum marker for the detection of HCC and its recurrence after surgery, with higher sensitivity and specificity than AFP. Clinical implementation of serum GP73 measurement as a standard test for HCC is recommended.
Authors:
Yilei Mao; Huayu Yang; Haifeng Xu; Xin Lu; Xinting Sang; Shunda Du; Haitao Zhao; Wang Chen; Yiyao Xu; Tianyi Chi; Zhiying Yang; Jianqiang Cai; Hui Li; Jianguo Chen; Shouxian Zhong; Smruti R Mohanti; Reynold Lopez-Soler; J Michael Millis; Jiefu Huang; Hongbing Zhang
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2010-09-28
Journal Detail:
Title:  Gut     Volume:  59     ISSN:  1468-3288     ISO Abbreviation:  Gut     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-12     Completed Date:  2010-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  England    
Other Details:
Languages:  eng     Pagination:  1687-93     Citation Subset:  AIM; IM    
Affiliation:
Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730 China. maoy@public3.bta.net.cn
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MeSH Terms
Descriptor/Qualifier:
Adult
Carcinoma, Hepatocellular / diagnosis*,  surgery
Diagnosis, Differential
Female
Hepatectomy
Hepatitis B / diagnosis
Humans
Liver Cirrhosis / diagnosis
Liver Neoplasms / diagnosis*,  surgery
Male
Membrane Proteins / blood*
Middle Aged
Neoplasm Proteins / blood
Sensitivity and Specificity
Tumor Markers, Biological / blood*
alpha-Fetoproteins / analysis
Chemical
Reg. No./Substance:
0/GOLM1 protein, human; 0/Membrane Proteins; 0/Neoplasm Proteins; 0/Tumor Markers, Biological; 0/alpha-Fetoproteins

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