Document Detail


Golgi positioning.
MedLine Citation:
PMID:  21504874     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Golgi apparatus in mammalian cells is positioned near the centrosome-based microtubule-organizing center (Fig. 1). Secretory cargo moves inward in membrane carriers for delivery to Golgi membranes in which it is processed and packaged for transport outward to the plasma membrane. Cytoplasmic dynein motor proteins (herein termed dynein) primarily mediate inward cargo carrier movement and Golgi positioning. These motors move along microtubules toward microtubule minus-ends embedded in centrosomes. Centripetal motility is controlled by a host of regulators whose precise functions remain to be determined. Significantly, a specific Golgi receptor for dynein has not been identified. This has impaired progress toward elucidation of membrane-motor-microtubule attachment in the periphery and, after inward movement, recycling of the motor for another round. Pericentrosomal positioning of the Golgi apparatus is dynamic. It is regulated during critical cellular processes such as mitosis, differentiation, cell polarization, and cell migration. Positioning is also important as it aligns the Golgi along an axis of cell polarity. In certain cell types, this promotes secretion directed to the proximal plasma membrane domain thereby maintaining specializations critical for diverse processes including wound healing, immunological synapse formation, and axon determination.
Authors:
Smita Yadav; Adam D Linstedt
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-05-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  3     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-03     Completed Date:  2011-09-09     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis
Axons / metabolism,  ultrastructure
Biological Transport
Cell Differentiation
Cell Membrane / metabolism,  ultrastructure
Cell Movement
Cell Polarity
Centrosome / metabolism
Dendrites / metabolism,  ultrastructure
Golgi Apparatus / physiology*,  ultrastructure
Intracellular Space / metabolism
Mammals / metabolism*
Microtubules / metabolism
Molecular Motor Proteins / metabolism,  physiology
Chemical
Reg. No./Substance:
0/Molecular Motor Proteins
Comments/Corrections

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