Document Detail

Golden grey mullet and sea bass oxidative DNA damage and clastogenic/aneugenic responses in a contaminated coastal lagoon.
MedLine Citation:
PMID:  20825987     Owner:  NLM     Status:  MEDLINE    
Several xenobiotics or their metabolites have redox-cycling properties and potential to induce oxidative stress and DNA damage. The current work aimed to study, under environmental conditions, oxidative DNA damage (8-hydroxy-2'-deoxyguanosine (8-OHdG)) and its association with chromosomal damage measured as erythrocytic nuclear abnormalities (ENAs), in Liza aurata and Dicentrarchus labrax, caught at a costal lagoon (Ria de Aveiro, Portugal) having sites with different contamination profiles. The quantified parameters were also used to assess the lagoon's environmental status. Five critical sites were assessed comparing to a reference site. L. aurata displayed higher 8-OHdG levels and ENAs frequency, respectively, at Laranjo and Vagos. D. labrax 8-OHdG levels were higher at the sites where quantification was possible whereas no differences were found in terms of ENAs. No correlation was found in both species between 8-OHdG and ENAs. Despite no direct linkage between the two biomarkers was found, this study demonstrates species and site dependent genotoxic responses.
M Oliveira; V L Maria; I Ahmad; M Teles; A Serafim; M J Bebianno; M Pacheco; M A Santos
Related Documents :
17364957 - Gene-specific oxidative lesions in aged rat brain detected by polymerase chain reaction...
11992737 - Bilirubin/biliverdin-cu(ii) induced dna breakage; reaction mechanism and biological sig...
25432747 - Synthesis of a biotinylated photocleavable nucleotide monophosphate for the preparation...
16780237 - Glutathione in blood cells decreases without dna breaks after a simulated saturation di...
16430687 - Evidence that the spoiiie dna translocase participates in membrane fusion during cytoki...
22997857 - Assessment of genetic damage in healthy and diseased tissue.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-09
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  73     ISSN:  1090-2414     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1907-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
CESAM & Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aneugens / toxicity
Bass / genetics,  metabolism*
DNA Damage / drug effects*
Deoxyguanosine / analogs & derivatives,  metabolism
Erythrocytes / cytology,  drug effects,  metabolism
Mutagens / toxicity*
Seawater / chemistry*
Smegmamorpha / genetics,  metabolism*
Water Pollutants, Chemical / toxicity*
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 0/Aneugens; 0/Mutagens; 0/Water Pollutants, Chemical; 961-07-9/Deoxyguanosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of celiprolol on prevention of cardiovascular events in vascular Ehlers-Danlos syndrome: a pr...
Next Document:  Copper tolerance and response of antioxidative enzymes in axenically grown Brassica juncea (L.) plan...