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Gold-silver-nanoclusters having cholic acid imprinted nanoshell.
MedLine Citation:
PMID:  22483924     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Molecular imprinted polymers (MIPs) as a recognition element for sensors are increasingly of interest and MIP-nanoparticles have started to appear in the literature. In this study, we have proposed a novel thiol ligand-capping method with polymerizable methacryloylamido-cysteine (MAC) attached to gold-silver-nanoclusters reminiscent of a self-assembled monolayer and have reconstructed surface shell by synthetic host polymers based on molecular imprinting method for cholic acid recognition. In this method, methacryloylamidohistidine-Pt(II) [MAH-Pt(II)] has used as a new metal-chelating monomer via metal coordination-chelation interactions and cholic acid. Nanoshell sensors with templates give a cavity that is selective for cholic acid. The cholic acid can simultaneously chelate to Pt(II) metal ion and fit into the shape-selective cavity. Thus, the interaction between Pt(II) ion and free coordination spheres has an effect on the binding ability of the gold-silver-nanoclusters nanosensor. The binding affinity of the cholic acid imprinted nanoparticles have investigated by using the Langmuir and Scatchard methods and determined affinity constant (K(affinity)) has found to be 2.73×10(4)molL(-1) and 2.13×10(8)molL(-1), respectively. At the last step of this procedure, cholic acid level in blood serum and urine which belong to a healthy people were determined by the prepared gold-silver-nanoclusters.
Authors:
Aytaç Gültekin; Arzu Ersöz; Adil Denizli; Rıdvan Say
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Publication Detail:
Type:  Journal Article     Date:  2012-03-03
Journal Detail:
Title:  Talanta     Volume:  93     ISSN:  1873-3573     ISO Abbreviation:  Talanta     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  364-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Department of Energy Systems Engineering, Karamanoğlu Mehmetbey University, Karaman, Turkey.
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