| Gold-silver-nanoclusters having cholic acid imprinted nanoshell. | |
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MedLine Citation:
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PMID: 22483924 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Molecular imprinted polymers (MIPs) as a recognition element for sensors are increasingly of interest and MIP-nanoparticles have started to appear in the literature. In this study, we have proposed a novel thiol ligand-capping method with polymerizable methacryloylamido-cysteine (MAC) attached to gold-silver-nanoclusters reminiscent of a self-assembled monolayer and have reconstructed surface shell by synthetic host polymers based on molecular imprinting method for cholic acid recognition. In this method, methacryloylamidohistidine-Pt(II) [MAH-Pt(II)] has used as a new metal-chelating monomer via metal coordination-chelation interactions and cholic acid. Nanoshell sensors with templates give a cavity that is selective for cholic acid. The cholic acid can simultaneously chelate to Pt(II) metal ion and fit into the shape-selective cavity. Thus, the interaction between Pt(II) ion and free coordination spheres has an effect on the binding ability of the gold-silver-nanoclusters nanosensor. The binding affinity of the cholic acid imprinted nanoparticles have investigated by using the Langmuir and Scatchard methods and determined affinity constant (K(affinity)) has found to be 2.73×10(4)molL(-1) and 2.13×10(8)molL(-1), respectively. At the last step of this procedure, cholic acid level in blood serum and urine which belong to a healthy people were determined by the prepared gold-silver-nanoclusters. |
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Authors:
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Aytaç Gültekin; Arzu Ersöz; Adil Denizli; Rıdvan Say |
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Publication Detail:
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Type: Journal Article Date: 2012-03-03 |
Journal Detail:
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Title: Talanta Volume: 93 ISSN: 1873-3573 ISO Abbreviation: Talanta Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984816R Medline TA: Talanta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 364-70 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Energy Systems Engineering, Karamanoğlu Mehmetbey University, Karaman, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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