| Gold nanoparticles protected with thiol-derivatized amphiphilic poly(epsilon-caprolactone)-b-poly(acrylic acid). | |
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MedLine Citation:
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PMID: 19053294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amphiphilic poly(epsilon-caprolactone)-b-poly(acrylic acid) (HS-PCL-b-PAA) with a thiol functionality in the PCL terminal has been prepared in a novel synthetic cascade. Initially, living anionic ring-opening polymerization (ROP) of epsilon-caprolactone (epsilon-CL) employing the difunctional initiator, 2-hydroxyethyl 2-bromoisobutyrate, followed by esterification with 2,4-dinitrophenyl- or 4-monomethoxytrityl-protected mercaptoacetic acids (Prot-), provided well-defined PCL macroinitiators capped with protected thiols. The macroinitiators allowed atom transfer radical polymerization (ATRP) of tert-butyl acrylate (tBA) in a controlled fashion by use of NiBr2(PPh3)2 catalyst to produce Prot-PCL-b-PtBA with narrow polydispersities (1.17-1.39). Subsequent mild deprotection protocols provided HS-PCL-b-PAA. Reduction of a gold salt in the presence of this macroligand under thiol-deficient conditions afforded stable, aggregation-free nanoparticles, as evidenced from UV-vis spectroscopy and transmission electron microscopy (TEM), the latter revealed nanoparticles with a mean diameter of 9.0+/-3.1 nm. |
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Authors:
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Irakli Javakhishvili; Søren Hvilsted |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomacromolecules Volume: 10 ISSN: 1526-4602 ISO Abbreviation: Biomacromolecules Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-12 Completed Date: 2009-03-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
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Languages: eng Pagination: 74-81 Citation Subset: IM |
Affiliation:
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Technical University of Denmark, Department of Chemical and Biochemical Engineering, Danish Polymer Centre, Building 423, DK-2800 Kgs. Lyngby, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acrylic Resins
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chemical synthesis,
chemistry* Gold / chemistry* Metal Nanoparticles / chemistry* Molecular Structure Particle Size Polyesters / chemical synthesis, chemistry* Sulfhydryl Compounds / chemistry* Surface-Active Agents / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Acrylic Resins; 0/Polyesters; 0/Sulfhydryl Compounds; 0/Surface-Active Agents; 0/poly(epsilon-caprolactone)-b-poly(acrylic acid); 7440-57-5/Gold |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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