Document Detail


Gold nanoparticles cellular toxicity and recovery: Adipose Derived Stromal cells.
MedLine Citation:
PMID:  23330784     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Gold nanoparticles (AuNPs) are used in various fields; however, their potential health risk(s) are still under the question. In this manuscript, we describe the interactions of AuNPs with human adipose derived stromal cells (ADSCs) and show that they are able to penetrate cell membrane and are stored in vacuoles. As expected, it was found that the uptake of the AuNPs is a function of time, their size and concentration as well as culture media used. Our results show that differentiation process of the ADSCs is affected by the presence of AuNPs and lead to the suppression of the adipogenesis by down regulation of adipogenic protein adiponectin and lipid accumulation inhibition. We also found significantly bigger decrease in fibronectin production in all samples exposed to AuNPs during the differentiation process. No changes were observed in collagen production. ADSCs wound healing ability was also inhibited by AuNPs in terms of cell migration and collagen contraction. Lastly, we also present data that indicates that AuNPs damage to cells is not permanent and that the cells can completely recover as a function of AuNPs size, concentration and exposure time.
Authors:
Tatsiana Mironava; Michael Hadjiargyrou; Marcia Simon; Miriam Rafailovich
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Nanotoxicology     Volume:  -     ISSN:  1743-5404     ISO Abbreviation:  Nanotoxicology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233132     Medline TA:  Nanotoxicology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Stony Brook University, Stem Cell Facility, Department of Medicine, Stony Brook, New York, United States, 11794.
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