Document Detail


Gold-induced thrombocytopenia.
MedLine Citation:
PMID:  209184     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ten patients with rheumatoid arhritis treated with gold sodium thiomalate developed thrombocytopenia without bone marrow asplasia. There was no life-threatening blood loss, but petechiae, purpura, or echymoses were seen in eight patients. The serum gold levels monitored in one patient did not exceed levels seen in patients without thrombocytopenia. In three cases peripheral blood lymphocytes were cultured in the presence of gold and tritiated thymidine incorporation was significantly increased. Eight patients responded to steroid therapy, one patient to BAL and pencillamine, and one patient to vincristine.
Authors:
M Harth; J P Hickey; W K Coulter; J M Thompson; T F Disney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  5     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1978  
Date Detail:
Created Date:  1978-09-15     Completed Date:  1978-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  165-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / therapeutic use
Adult
Aged
Arthritis, Rheumatoid / drug therapy*
Dimercaprol / therapeutic use
Female
Gold Sodium Thiomalate / adverse effects*
Humans
Male
Middle Aged
Penicillamine / therapeutic use
Prednisone / therapeutic use
Thrombocytopenia / chemically induced*
Vincristine / therapeutic use
Chemical
Reg. No./Substance:
12244-57-4/Gold Sodium Thiomalate; 52-67-5/Penicillamine; 53-03-2/Prednisone; 57-22-7/Vincristine; 59-52-9/Dimercaprol; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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