Document Detail


Gold nanoparticle-fluorophore complexes: sensitive and discerning "noses" for biosystems sensing.
MedLine Citation:
PMID:  20405519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Gold nanoparticles (NPs) efficiently quench adsorbed fluorophores. Upon disruption of such complexes by an analyte, fluorescence turn-on is observed. By judicious choice of the functionalized NP and the fluorophore, these complexes display different responses to analytes, thus leading to versatile yet simple array-based sensor platforms. Using this strategy, we can identify proteins in buffer and serum, distinguish between both different species and different strains of bacteria, and differentiate between healthy, cancerous, and metastatic human and murine cells.
Authors:
Uwe H F Bunz; Vincent M Rotello
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  49     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  3268-79     Citation Subset:  IM    
Affiliation:
School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA. uwe.bunz@chemistry.gatech.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria / isolation & purification
Biosensing Techniques
Diphosphates / chemistry
Fluorescent Dyes / chemistry*
Gold / chemistry*
Humans
Metal Nanoparticles / chemistry*
Mice
Microarray Analysis
Polymers / chemistry
Proteins / chemistry
Grant Support
ID/Acronym/Agency:
AI073425/AI/NIAID NIH HHS; GM077173/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Diphosphates; 0/Fluorescent Dyes; 0/Polymers; 0/Proteins; 7440-57-5/Gold

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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