| Gold nanoparticle-fluorophore complexes: sensitive and discerning "noses" for biosystems sensing. | |
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MedLine Citation:
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PMID: 20405519 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gold nanoparticles (NPs) efficiently quench adsorbed fluorophores. Upon disruption of such complexes by an analyte, fluorescence turn-on is observed. By judicious choice of the functionalized NP and the fluorophore, these complexes display different responses to analytes, thus leading to versatile yet simple array-based sensor platforms. Using this strategy, we can identify proteins in buffer and serum, distinguish between both different species and different strains of bacteria, and differentiate between healthy, cancerous, and metastatic human and murine cells. |
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Authors:
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Uwe H F Bunz; Vincent M Rotello |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Angewandte Chemie (International ed. in English) Volume: 49 ISSN: 1521-3773 ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-27 Completed Date: 2010-07-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: Germany |
Other Details:
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Languages: eng Pagination: 3268-79 Citation Subset: IM |
Affiliation:
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School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, GA 30332, USA. uwe.bunz@chemistry.gatech.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bacteria / isolation & purification Biosensing Techniques Diphosphates / chemistry Fluorescent Dyes / chemistry* Gold / chemistry* Humans Metal Nanoparticles / chemistry* Mice Microarray Analysis Polymers / chemistry Proteins / chemistry |
| Grant Support | |
ID/Acronym/Agency:
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AI073425/AI/NIAID NIH HHS; GM077173/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Diphosphates; 0/Fluorescent Dyes; 0/Polymers; 0/Proteins; 7440-57-5/Gold |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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