Document Detail

Goitre and iodine deficiency in Afghanistan: a case-control study.
MedLine Citation:
PMID:  16441934     Owner:  NLM     Status:  MEDLINE    
I deficiency is the leading cause of preventable mental retardation. A number of surveys in Afghanistan show goitre prevalence rates more than 20 % amongst children and women. Access to iodised salt remains low, with disparate coverage by region, despite the recent implementation of a national salt iodisation programme. The objectives were to identify whether the presence of goitre is a satisfactory marker of I deficiency and to examine the relationship between goitre and thyroid function. A case-control study was carried out in children and women of childbearing age, stratified on the presence of goitre. Adequate levels of urinary I were observed in 6.8 % of all the subjects, and amongst the subjects without goitre, this figure was only 9 %. The presence of goitre was significantly associated with severe urinary I deficiency; however, the difference between the cases and controls was not as great as expected. An association between the presence of goitre and elevated thyroid-stimulating hormone (TSH) levels was observed, but 14 % of the children without palpable goitre also showed abnormal TSH levels.Given that the majority of subjects showed some degree of I deficiency and that children without goitre may have elevated TSH levels, the absence of goitre is an insufficient indicator to determine adequate I status. The risk of subsequent development of goitre, in the currently non-goitre population, is elevated. This suggests that short-term I supplementation should be considered independently of the presence of goitre or urinary I level, until the access to and consumption of iodised salt is generalised.
Odile Oberlin; Emmanuelle Plantin-Carrenard; Odile Rigal; Caroline Wilkinson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  95     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-30     Completed Date:  2006-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  196-203     Citation Subset:  IM    
Action Contre la Faim, 4 rue Niepce, 75014 Paris, France.
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MeSH Terms
Afghanistan / epidemiology
Age Distribution
Body Mass Index
Case-Control Studies
Child Development / physiology
Child, Preschool
Goiter / epidemiology*,  physiopathology
Infant Mortality
Intelligence Tests
Iodine / deficiency*,  urine
Pregnancy Complications / epidemiology
Sex Distribution
Thyroid Gland / physiopathology
Reg. No./Substance:

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