| Goiter associated with acromegaly: sonographic and scintigraphic findings of the thyroid gland. | |
| | |
MedLine Citation:
|
PMID: 10482372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Elevation in serum human growth hormone (GH) level is known to be a factor that causes goiter development. The present study was designed to analyze sonographic and scintigraphic appearances of the thyroid in patients with acromegaly. The records of 48 consecutive patients with acromegaly were examined. Two patients had a history of operation for thyroid cancer. One had an atrophic thyroid gland after 131I treatment for Graves' disease. Goiter was palpable in 39 of the remaining 45 patients. Neither ultrasonography (US) nor scintigraphy was performed in 17 patients, including 6 with no palpable goiter and 11 with small diffuse goiter (group 1). Of the remaining 28 patients who underwent US, 14 had a moderately or markedly enlarged diffuse goiter (group 2), 13 were diagnosed as having adenomatous goiter (group 3), and 1 had a solitary cystic nodule. Among 11 patients in group 3 who underwent 123I or 99mTc thyroid scintigraphy, 6 showed uneven uptake, and 2 with undetectably reduced levels of thyrotropin (TSH) showed localized functioning areas. The mean serum TSH concentration in group 3 was significantly lower than that in group 1 or 2 (p<0.01). The duration of illness as acromegaly was significantly longer in group 2 and 3 as compared with group 1 (p<0.05). These results suggest that long-term stimulation by GH and insulin-like growth factor-I of thyroid follicular cells might be responsible for thyroid enlargement, presence of functioning lesions, slight overactivity of the thyroid, and the subsequent formation of multiple nodules in acromegalic patients. In conclusion, excluding two patients with thyroid cancer and one with Graves' disease, goiter was palpable in 39 of the 45 patients with acromegaly, among whom 14 (13 adenomatous goiters and 1 solitary cystic nodule) showed nodular enlargement. |
| | |
Authors:
|
K Kasagi; A Shimatsu; S Miyamoto; T Misaki; H Sakahara; J Konishi |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Thyroid : official journal of the American Thyroid Association Volume: 9 ISSN: 1050-7256 ISO Abbreviation: Thyroid Publication Date: 1999 Aug |
Date Detail:
|
Created Date: 1999-10-19 Completed Date: 1999-10-19 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9104317 Medline TA: Thyroid Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 791-6 Citation Subset: IM |
Affiliation:
|
Department of Nuclear Medicine, Kyoto University School of Medicine, Japan. kkasa@kuhp.kyoto-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acromegaly
/
complications*,
radionuclide imaging,
ultrasonography Adult Female Goiter / complications*, radionuclide imaging, ultrasonography Graves Disease / radionuclide imaging, ultrasonography Humans Male Middle Aged Thyroid Function Tests Thyroid Gland / radionuclide imaging*, ultrasonography* Thyroid Hormones / blood Thyrotropin / blood Thyrotropin-Releasing Hormone / blood |
| Chemical | |
Reg. No./Substance:
|
0/Thyroid Hormones; 24305-27-9/Thyrotropin-Releasing Hormone; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Electrodermal activity in hypothyroid patients and healthy subjects.
Next Document: Imaging of locally recurrent and metastatic thyroid cancer with positron emission tomography.