Document Detail


Goblet cells: are they an unspecific barrier against Giardia intestinalis or a gate?
MedLine Citation:
PMID:  18038237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Giardiosis is one of the major intestinal parasitic diseases of human beings as well as wild and domesticated animals. Several protective mechanisms against infection have been described. However, specific information about relationship between giardiosis and the increased proliferation of goblet cells (GC) in patients infected with Giardia intestinalis (Syn. G. duodenalis, G. lamblia) is scarce. In this work, we compare and quantify the number of GC, and have inferred their metabolic state in the small intestine of dogs parasitized with Giardia intestinalis compared to dogs without parasites. Small intestine segments were processed using routine methods for histology and electron microscopy; areas and cells were screened with an Axiovision Ver. 4.0 system. Data were analyzed by ANOVA and comparison of averages. Parasitized dogs showed higher GC numbers than nonparasitized ones. Averages were: 20+/-0.81 GC/25 microm(2) with independent mucin granules and 11+/-1.53 GC/25 microm(2) that were expelling mucus, compared to 11+/-0.94 GC/25 microm(2) and 1+/-0.27 GC/25 microm(2), respectively, in nonparasitized dogs (Tukey, p<0.001). The increases in GC number seem to be an unspecific defensive mechanism against Giardia trophozoites. However, we found some evidence supporting that GC hyperplasia could be a prejudicial to epithelial barrier that gives rise to gates allowing for Giardia-tissue invasion.
Authors:
Martha Ponce-Macotela; Angélica González-Maciel; Rafael Reynoso-Robles; Mario N Martínez-Gordillo
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Publication Detail:
Type:  Journal Article     Date:  2007-11-25
Journal Detail:
Title:  Parasitology research     Volume:  102     ISSN:  0932-0113     ISO Abbreviation:  Parasitol. Res.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-25     Completed Date:  2009-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703571     Medline TA:  Parasitol Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  509-13     Citation Subset:  IM    
Affiliation:
Parasitología Experimental, Instituto Nacional de Pediatría, Insurgentes Sur No. 3700-C, México, D.F. C.P. 04530, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Dogs
Giardia lamblia / pathogenicity*
Giardiasis / pathology,  prevention & control*,  transmission*
Goblet Cells / parasitology*
Intestine, Small / parasitology*

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