Document Detail

Goal-directed and transfer-cue-elicited drug-seeking are dissociated by pharmacotherapy: Evidence for independent additive controllers.
MedLine Citation:
PMID:  22823420     Owner:  NLM     Status:  In-Data-Review    
According to contemporary learning theory, drug-seeking behavior reflects the summation of 2 dissociable controllers. Whereas goal-directed drug-seeking is determined by the expected current incentive value of the drug, stimulus-elicited drug-seeking is determined by the expected probability of the drug independently of its current incentive value, and these 2 controllers contribute additively to observed drug-seeking. One applied prediction of this model is that smoking cessation pharmacotherapies selectively attenuate tonic but not cue-elicited craving because they downgrade the expected incentive value of the drug but leave expected probability intact. To test this, the current study examined whether nicotine replacement therapy (NRT) nasal spray would modify goal-directed tobacco choice in a human outcome devaluation procedure, but leave cue-elicited tobacco choice in a Pavlovian to instrumental transfer (PIT) procedure intact. Smokers (N= 96) first underwent concurrent choice training in which 2 responses earned tobacco or chocolate points, respectively. Participants then ingested either NRT nasal spray (1 mg) or chocolate (147 g) to devalue 1 outcome. Concurrent choice was then tested again in extinction to measure goal-directed control of choice, and in a PIT test to measure the extent to which tobacco and chocolate stimuli enhanced choice of the same outcome. It was found that NRT modified tobacco choice in the extinction test but not the extent to which the tobacco stimulus enhanced choice of the tobacco outcome in the PIT test. This dissociation suggests that the propensity to engage in drug-seeking is determined independently by the expected value and probability of the drug, and that pharmacotherapy has partial efficacy because it selectively effects expected drug value. (PsycINFO Database Record (c) 2012 APA, all rights reserved).
Lee Hogarth
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of experimental psychology. Animal behavior processes     Volume:  38     ISSN:  1939-2184     ISO Abbreviation:  J Exp Psychol Anim Behav Process     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7504289     Medline TA:  J Exp Psychol Anim Behav Process     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-78     Citation Subset:  IM    
School of Psychology, University of New South Wales.
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