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The GnRH antagonist protocol - the protocol of choice for the PCOS patient undergoing controlled ovarian stimulation.
MedLine Citation:
PMID:  22428986     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Polycystic ovary syndrome (PCOS) patients are prone to develop ovarian hyperstimulation syndrome (OHSS), a condition which can be minimized or completely eliminated by the use of gonadotropin-releasing hormone agonist (GnRHa) trigger. In this opinion paper we maintain that the GnRH antagonist protocol should be the protocol of choice for the PCOS patient undergoing ovarian stimulation with gonadotropins for IVF. If an excessive ovarian response is encountered, the clinician will always have two options: either to trigger final oocyte maturation with a bolus of GnRHa and supplement the luteal phase with a small bolus of human chorionic gonadotropin (hCG) in addition to the standard luteal phase support and transfer in the fresh cycle or alternatively to trigger with GnRHa and perform a total freeze, resulting in a complete elimination of OHSS and high ongoing pregnancy rates in the subsequent frozen thaw transfer cycles.
Authors:
Shahar Kol; Roy Homburg; Birgit Alsbjerg; Peter Humaidan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-19
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
Department of Obstetrics and Gynecology, IVF Unit, Rambam Medical Center, Haifa, Israel Barzilai Medical Center, Ashkelon, Israel and Homerton University Hospital, London, UK The Fertility Clinic, Skive Regional Hospital, Skive, Denmark The Fertility Clinic, Department D, Odense University Hospital, Odense, Denmark.
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