Document Detail

Glypican-4 is increased in human subjects with impaired glucose tolerance and decreased in patients with newly diagnosed type 2 diabetes.
MedLine Citation:
PMID:  25240528     Owner:  NLM     Status:  Publisher    
CONTEXT: Glypican-4 (GPC-4) has been identified as a novel adipokine capable of enhancing insulin signaling. A significant association between circulating GPC-4 levels and nonalcoholic fatty liver disease and cardiometabolic risk factors has been found in women.
OBJECTIVE: The aim of the present study was to investigate the relationship between GPC-4 and insulin resistance in cross-sectional and interventional studies.
PATIENTS AND DESIGN: We measured circulating GPC-4 (determined with ELISA) in subjects with NGT, IGT, and nT2DM. Euglycemic-hyperinsulinemic clamps were performed in healthy and T2DM subjects. Real-time RT-PCR and Western blotting were used to assess mRNA and protein expression of GPC-4.
RESULTS: Circulating GPC-4 levels were significantly higher in IGT subjects and lower in nT2DM subjects compared to controls. Circulating GPC-4 was positively correlated with BMI, WHR, HOMA-IS, and FAT%, while it was inversely correlated with FBG and HbA1c. Excluding diabetic subjects, increasing GPC-4 levels were associated with HOMA-IR and M values. Significantly lower GPC-4 mRNA and protein levels were found in muscle and fat of nT2DM patients, compared to controls. GPC-4 levels were significantly increased upon an oral glucose intake. The secretion of GPC-4 exhibited a characteristic diurnal rhythm in humans, with a major rise occurring between afternoon and midnight.
CONCLUSIONS: Circulating GPC-4 is elevated in prediabetic subjects and is reduced in nT2DM patients. The elevated GPC-4 appears to be associated with insulin resistance and obesity in IGT subjects.
Ke Li; Xiaohui Xu; Wenjing Hu; Minyan Li; Mengliu Yang; Yaxu Wang; Yong Luo; Xianxiang Zhang; Hua Liu; Ling Li; Gangyi Yang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-21
Journal Detail:
Title:  Acta diabetologica     Volume:  -     ISSN:  1432-5233     ISO Abbreviation:  Acta Diabetol     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200299     Medline TA:  Acta Diabetol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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