Document Detail


Glyphosate herbicide formulation: a potentially lethal ingestion.
MedLine Citation:
PMID:  15228468     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glyphosate surfactant herbicide (GlySH) toxicity is an uncommon poisoning. We report two fatalities involving suicidal ingestion of this herbicide. Both deaths occurred despite early recognition of the serious nature of the poisoning and aggressive treatment. The deaths in this series are analysed in the context of a review of existing literature. Although traditionally regarded as minimally toxic, many deaths have been reported following suicidal ingestion. Severe GlySH toxicity may be refractory even to the most intensive supportive care. The triad of pulmonary oedema, metabolic acidosis and hyperkalaemia portends poor outcome. While containing a carbon phosphorus moiety, GlySH does not exhibit organophosphate toxicity. A clinical guide to assessing severity of GlySH toxicity is proposed and treatment modalities discussed.
Authors:
Julian Stella; Matthew Ryan
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Emergency medicine Australasia : EMA     Volume:  16     ISSN:  1742-6731     ISO Abbreviation:  Emerg Med Australas     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-01     Completed Date:  2004-09-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101199824     Medline TA:  Emerg Med Australas     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
Affiliation:
Department of Emergency Medicine, Geelong Hospital, Geelong, Victoria, Australia. julianst@barwonhealth.org.au
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MeSH Terms
Descriptor/Qualifier:
Acidosis / chemically induced,  therapy
Administration, Oral
Adult
Aged
Emergency Medicine / methods*
Fatal Outcome
Glycine / analogs & derivatives*,  poisoning*
Herbicides / poisoning*
Humans
Hyperkalemia / chemically induced,  therapy
Hypotension / chemically induced,  therapy
Male
Overdose
Suicide
Chemical
Reg. No./Substance:
0/Herbicides; 1071-83-6/glyphosate; 56-40-6/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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