Document Detail

Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.
MedLine Citation:
PMID:  22893478     Owner:  NLM     Status:  Publisher    
The glyoxalase enzymes catalyse the conversion of reactive glucose metabolites into non-toxic products as a part of the cellular defence system against glycation. This study investigated changes in glyoxalase 1 and glyoxalase 2 activities and the development of diabetic complications in experimental animal models of obesity (Zucker fa/fa rats) and type 2 diabetes mellitus (Goto-Kakizaki rats). In contrast to Zucker rats, in Goto-Kakizaki rats the glyoxalase 1 activities in brain, spinal cord and sciatic nerve tissues were significantly reduced by 10, 32 and 36 %, respectively. Lower glyoxalase 1 activity in the neuronal tissues was associated with a higher blood glucose concentration and impaired endothelium-dependent relaxation to acetylcholine in aortic rings in Goto-Kakizaki rats. This study provides evidence for disturbed neuronal glyoxalase 1 activity under conditions of hyperglycaemia in the presence of impaired endothelium-dependent relaxation and cognitive function.
Elina Skapare; Ilze Konrade; Edgars Liepinsh; Marina Makrecka; Liga Zvejniece; Baiba Svalbe; Reinis Vilskersts; Maija Dambrova
Related Documents :
16865328 - Negative association between occurrence of type 1 diabetes and tuberculosis incidence a...
11810468 - Glomerular structural changes and structural-functional relationships at early stage of...
15910628 - Calcaneal bone mineral density in patients with charcot neuropathic osteoarthropathy: d...
15925018 - Diabetes mellitus in children and adolescents.
18358848 - Redox imbalance in parkinson's disease.
395068 - The artificial beta cell (biostator) in the adjustment of instable diabetics--results a...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-15
Journal Detail:
Title:  The journal of physiological sciences : JPS     Volume:  -     ISSN:  1880-6562     ISO Abbreviation:  J Physiol Sci     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262417     Medline TA:  J Physiol Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, Riga, LV1006, Latvia,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Socio-economic factors affect mortality in 47,XYY syndrome-A comparison with the background populati...
Next Document:  Autonomic boundary conditions for ventricular fibrillation and their implications for a novel defibr...