| Glyoxal-induced premature senescence in human fibroblasts. | |
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MedLine Citation:
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PMID: 17460217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mild stress-induced hormesis is an effective strategy to intervene in the aging process. Repeated exposure of human skin fibroblasts to 41 degrees C heat shock for 1 h twice a week is an example of mild stress that has many hormetic effects, including improved resistance to other stressors. We are now developing an experimental model system of sugar-induced premature senescence, which can be useful to test the hormetic and antiaging effects of other stresses. Our present studies show that early-passage human skin fibroblasts treated with 1 mM glyoxal for 72 h undergo premature senescence in terms of enlarged cell size, inhibition of cell division, slowing down of cell growth, a decrease in the number of DNA synthesizing cells, and increased resistance to apoptosis. |
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Authors:
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Henrik Sejersen; Suresh I S Rattan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the New York Academy of Sciences Volume: 1100 ISSN: 0077-8923 ISO Abbreviation: Ann. N. Y. Acad. Sci. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-26 Completed Date: 2007-05-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7506858 Medline TA: Ann N Y Acad Sci Country: United States |
Other Details:
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Languages: eng Pagination: 518-23 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK8000 Aarhus-C, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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metabolism Apoptosis Bromodeoxyuridine / pharmacology Cell Aging / drug effects* Cells, Cultured DNA / metabolism DNA Damage Dose-Response Relationship, Drug Fibroblasts / metabolism* Glyoxal / chemistry, pharmacology* Humans Oxidative Stress Phenotype Skin / cytology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 107-22-2/Glyoxal; 59-14-3/Bromodeoxyuridine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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